human granulocyte colony stimulating factor (hg-csf) induces proliferation and differentiation of granulocyte progenitor cells. this glycoprotein is currently being used for treatment of neutropenia, in patients who have undergone bone marrow transplantation. so far, different researchers have tried to enhance hg-csf biological activity and stability. in this study, polymerase chain reaction (p...

Site-directed mutagenesis is a powerful tool for producing mutants to assess the importance of specific amino acid residues in a protein’s structure and/or function. We wanted to generate mutants of human ETS1 cDNA in the pET15b vector (Novagen, Madison, WI, USA) from which we had been producing wild-type protein for structural studies (11). Since we were subject to the constraints of this vect...

word count: 178 Manuscript word count: 4936 Blood First Edition Paper, prepublished online June 16, 2005; DOI 10.1182/blood-2004-12-4840 Copyright © 2005 American Society of Hematology only. For personal use at PENN STATE UNIVERSITY on February 23, 2013. bloodjournal.hematologylibrary.org From

We developed several novel tools to genome wide screen for CNVs and SNPs in single cells. When applied to cleavage stage embryos from young fertile couples we discovered, unexpectedly, an extremely high incidence of chromosomal instability, a hallmark of tumorigenesis (Vanneste et al., Nature Medicine, 2009; Vanneste et al., Hum.Reprod., 2011). Not only mosaicisms for whole chromosome aneuploid...

The global pollution of environment urges the screening effective natural protectors for correc-tion toxic and genotoxic action xenobiotics. Medicinal herbs contain a complex biologically ac-tive compounds that are potential sources such protective agent. In current study mutagenic antimutagenic activity alcoholic extracts peppermint (Mentha piperita L.) thyme (Thymus vulgaris L.), family Lamia...

australian grapevine viroid (agvd), an apscaviroid of the family pospiviroidae, was recently identified in vineyards of southern iran. it had a relatively wide host range and caused stunting, leaf deformation, mottling and vein clearing in experimental hosts upon mechanical inoculation of nucleic acid extracts or agroinfiltration of the viroid infectious cloned dna. predicted secondary structur...

introduction: active packaging is one of the innovations in food packaging industry that would be a respons to the changing needs of consumers and markets. in this technique, materials such as adsorbents oxygen, moisture, carbon dioxide, ethylene and carbon dioxide-releasing flavor compounds, antimicrobials, antioxidants and various aromatic compounds are used. in the last decade, great attenti...