background: breast cancer (bc) is the second most commonly diagnosed cancer after lung cancer. survival of bc patients is affected by intermediate events. this study was aimed to investigate the disease course of primary non-metastatic bc patients with first recurrence of the tumor (frt) as the intermediate event using the illness- death model. methods: this retrospective cohort study was condu...

Introduction: Gallbladder carcinoma is the most common biliary tract carcinoma. A subset develops in polypoidal precursors that are detectable by ultrasound but not reliably distinguishable from non-neoplastic polyps. Most guidelines recommend cholecystectomy for polyps ≥ 10mm based on a higher rate of neoplasia, however, disagreements exist with management recommendations smaller incidentally ...

BACKGROUND In order to optimise the cost-effectiveness of active surveillance to substantiate freedom from disease, a new approach using targeted sampling of farms was developed and applied on the example of infectious bovine rhinotracheitis (IBR) and enzootic bovine leucosis (EBL) in Switzerland. Relevant risk factors (RF) for the introduction of IBR and EBL into Swiss cattle farms were identi...

  Background and aims: <span style="color: #221e1f; font-family: Optima ...