The influence of sodium lauryl sulfate (SLS) on the efficacies of topical gel formulations of foscarnet against herpes simplex virus type 1 (HSV-1) cutaneous infection has been evaluated in mice. A single application of the gel formulation containing 3% foscarnet given 24 h postinfection exerted only a modest effect on the development of herpetic skin lesions. Of prime interest, the addition of...

Stochastic Local Search (SLS) is a simple and effective paradigm for attacking a variety of Combinatorial (Optimization) Problems (COP). However, it is often non-trivial to get good results from an SLS; the designer of an SLS needs to undertake a laborious and ad-hoc algorithm tuning and re-design process for a particular COP. There are two general approaches. Black-box approach treats the SLS ...

Sjögren-Larsson syndrome (SLS) is an inherited neurocutaneous disorder characterized by ichthyosis, mental retardation, spasticity, and deficient activity of fatty aldehyde dehydrogenase (FALDH). FALDH is an enzyme component of fatty alcohol:NAD oxidoreductase (FAO), which is necessary for fatty alcohol metabolism. To better understand the biochemical basis for the cutaneous symptoms in this di...

The passive elasticity of the sarcomere in striated muscle is determined by large modular proteins, such as titin in vertebrates. In insects, the function of titin is divided between two shorter proteins, projectin and sallimus (Sls), which are the products of different genes. The Drosophila sallimus (sls) gene codes for a protein of 2 MDa. The N-terminal half of the protein is largely made up ...

Shrinking lung syndrome (SLS) is a rare manifestation of systemic lupus erythematosus. We report the case of a patient with non-responding SLS (neither to glucocorticoids nor immunosupresors), who showed remarkable improvement after the onset of treatment with rituximab. Although there is a little evidence, treatment with rituximab could be proposed in SLS when classical treatment fails.

The passive elasticity of the sarcomere in striated muscle is determined by large modular proteins, such as titin in vertebrates. In insects, the function of titin is divided between two shorter proteins, projectin and sallimus (Sls), which are the products of different genes. The Drosophila sallimus (sls) gene codes for a protein of 2 MDa. The N-terminal half of the protein is largely made up ...

This paper engineers a new state-of-the-art Stochastic Local Search (SLS) for the Low Autocorrelation Binary Sequence (LABS) problem. The new SLS solver is obtained with white-box visualization to get insights on how an SLS can be effective for LABS; implementation improvements; and black-box parameter tuning.

Recent work on Stochastic Local Search (SLS) for the SAT and CSP domains has shown the superior performance of SLS over traditional backtracking algorithms on a broad range of problem instances. In this paper, we report on a technique for enhancing the performance of SLS solvers by incorporating a preprocessing phase in which resolution is used to deduce consequences of the input clauses, expos...