Byssinosis, a lung disease that can affect cotton mill workers, may be caused in part by lipopolysaccharides (LPS) from Gram negative bacteria. In vitro, LPS complexes with sheep lung surfactant (SLS). To determine whether LPS in extracts of cotton dust alters the biophysical characteristics of lung surfactant, aqueous extracts (1.0% w:v) of sterile surgical cotton (SSC) and a bulk raw cotton d...

Sjogren-Larsson syndrome (SLS) is an inherited disorder associated with impaired fatty alcohol oxidation due to deficient activity of fatty alcohol:NAD+ oxidoreductase (FAO). FAO is a complex enzyme which consists of two separate proteins that sequentially catalyze the oxidation of fatty alcohol to fatty aldehyde and fatty acid. To determine which enzymatic component of FAO was deficient in SLS...

The human pathogen Streptococcus pyogenes secretes a highly cytolytic toxin known as streptolysin S (SLS). SLS is a key virulence determinant and responsible for the beta-hemolytic phenotype of these bacteria. Despite over a century of research, the chemical structure of SLS remains unknown. Recent experiments have revealed that SLS is generated from an inactive precursor peptide that undergoes...

We study a framework called BC SLS for a novel type of stochastic local search (SLS) for propositional satisfiability (SAT). Aimed specifically at solving real-world SAT instances, the approach works directly on a non-clausal structural representation for SAT. This allows for don’t care detection and justification guided search heuristics in SLS by applying the circuit-level SAT technique of ju...

Strigolactones are a novel class of plant hormones produced in roots that regulate shoot and root development. We previously reported that strigolactone analogs (SLs) induce G2/M cell cycle arrest and apoptosis in a variety of human cancer cells and inhibit tumor growth of human breast cancer xenografts in mice. SLs had no significant influences on non-transformed cells. Here we report for the ...

A laparoscopic radical nephrectomy (LRN) for renal cancer can be performed using two methods, hand-assisted laparoscopic surgery (HALS) and standard laparoscopic surgery (SLS). This institute initially used HALS to perform all radical nephrectomy, but gradually shifted to SLS. This study compared the two methods of radical nephrectomy: HALS vs. SLS, which were performed at a single institute. F...

Using animal models, we have examined the effects in the eye of one of the detergents, sodium lauryl sulfate (SLS), that is included in soaps and shampoos. We also have determined how SLS is taken up by the eye. Four findings have ensued: first, SLS is rapidly taken up and accumulated by eye tissues. SLS is retained for up to five days in most eye tissues. Second, SLS uptake is greater in young...

The role of sphingolipids (SLs) in the immune system has come under increasing scrutiny recently due to the emerging contributions that these important membrane components play in regulating a variety of immunological processes. The acyl chain length of SLs appears particularly critical in determining SL function. Here, we show a role for very-long acyl chain SLs (VLC-SLs) in invariant natural ...

Bulent Berker, MD, Salih Taskin, MD, Elif Aylin Taskin, MD INTRODUCTION Approximately 30 years after its introduction, the use of laparoscopy in gynecology has expanded from diagnosis and tubal sterilization to more sophisticated operations and is even being used for the management of malignancies. Despite rapidly improving technical equipment and surgical skill, complication rates and preventa...