SNP Genotyping In article number 2105538, Jungkyu Choi, Hyojin Lee, Nakwon an co-workers present SWITCH for multiplex single nucleotide polymorphism genotyping. Invaders (single-stranded oligonucleotides, colored in blue and yellow) obtained from a gold nanoparticle induce fluorescence recovery specific regions of shape-coded hydrogel microparticle.

In this review, we consider the motivation behind contemporary single nucleotide polymorphism (SNP) initiatives. Many of these initiatives are projected to involve large, population-based surveys. We therefore emphasize the utility of SNPs for genetic epidemiology studies. We start by offering an overview of genetic polymorphism and discuss the historical use of polymorphism in the identificati...

diabetes mellitus (dm) is a chronic heterogeneous disorder and oxidative stress is a key participant in the development and progression of it and its complications. anti-oxidant status can affect vulnerability to oxidative damage, onset and progression of diabetes and diabetes complications. superoxide dismutase 2 (sod2) is one of the major antioxidant defense systems against free radicals. sod...

adenosine deaminase (ada) is an important regulator of insulin action. the single nucleotide polymorphism (snp) g22a in the ada gene decreases enzymatic activity of ada. the aim of this study was to investigate the relationship between the snp g22a and blood glycemic control, insulin resistance, and obesity of gestational diabetes mellitus (gdm) patients in an iranian population. snp g22a was d...

Uncovering DNA sequence variations that correlate with phenotypic changes, e.g., diseases, is the aim of sequence variation studies. Common types sequence variations are Single nucleotide polymorphism (SNP, pronounced snip).SNPs are the third-generation molecular marker. SNP represents a DNA sequence variant of a single base pair with the minor allele occurring in more than 1% of a given popula...

The aims of the present study were to propose apolymerase chain reaction-restriction fragment length polymorphismPCR-RFLP genotyping method for the AY_376689:c.773C>T single nucleotide polymorphism SNP of the equine PRKAG3 gene, related to muscle performance, as well as to characterize this SNP and a second polymorphism, AAWR_02017454:g.121684T>C of the SPATA1 gene, related to male fertility, i...

The purpose of this study was to investigate whether an association exists between the promoter region of the prostacyclin synthase gene and essential hypertension (EH). Using the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) method, we discovered a novel single nucleotide polymorphism (SNP), T-192G, in the 5'-flanking region. We performed an association study usi...