Submit Manuscript | http://medcraveonline.com Abbreviations: SLN: Solid Lipid Nanoparticles; PQ-SLNs: PQLoaded Solid Lipid Nanoparticles; o/w: Oil-in-Water; SA: Stearic Acid; PVA: Polyvinyl Alcohol; EtOAc: Ethyl Acetate; w/o: Waterin-Oil; PDI: Poly Dispersity Index; DLS: Dynamic Light Scattering; FD: Freeze Drying; HEPES: N-2-Hydroxyethylpiperazine-N-2Ethanesulfonic Acid; NP: Nanoformulated Pri...

This paper aims to encapsulate into solid lipid nanoparticles a mixture of two bioactive compounds, a photoprotective agent and an antioxidant compound. The co-encapsulation effect of octocrylene sunscreen and flavonoid (luteolinon) has been studied on the specific properties like antioxidant activity, sun protection factor and photostability. Using the high preasure homogenization technique li...

Colloidal lipid particles such as solid lipid nanoparticles and liquid crystalline nanoparticles have great opportunities as drug carriers especially for lipophilic drugs intended for intravenous administration. In order to evaluate drug release from these nanoparticles and determine their behavior after administration, emulsion droplets were used as a lipophilic compartment to which the transf...

The aim of this study was to understand and investigate the relationship between experimental factors and their responses in the preparation of ciprofloxacin hydrochloride based solid lipid nanoparticles. A quadratic relationship was studied by developing central composite rotatable design. Amount of lipid and drug, stirring speed and stirring time were selected as experimental factors while pa...

have attracted a lot of interest to develop health and wellness promoting foods and beverages. However, bioactive lipids are water-insoluble and degrade easily during processing and storage, making their addition into foods and beverages challenging. The main objective of this thesis was to develop a novel green process to form bioactive lipid-carrier hollow solid lipid micro-and nanoparticles ...

Small interfering RNA (siRNA) is a highly potent drug in gene-based therapy with a challenge of being delivered in a sustained manner. Nanoparticle drug delivery systems allow for incorporating and controlled release of therapeutic payloads. We demonstrate that solid lipid nanoparticles can incorporate and provide sustained release of siRNA. Tristearin solid lipid nanoparticles, made by nanopre...

colloidal carriers composed of lipids attract much attention in the development of safer and more effective therapy of various diseases. the advantages of lipid-based nanoparticles are illustrated on the example of paclitaxel, a challenging chemotherapeutic drug for the development of a novel and more suitable dosage form for cancer treatment. paclitaxel is known for its water insolubility and ...

The candesartan cilexetil belongs to class II of the biopharmaceutical classification system and bioavailability is 15% due to the poor aqueous solubility. The purpose of the study is to improve aqueous solubility by nano technology of solid lipid nanoparticle by solvent evaporation method. Here glyceryl monosterate (lipid), polaxemor 407, tweeen 80 (co-surfactant and surfactant respectively) a...