The purpose of this study was to use solid lipid nanoparticles (SLN) to improve the pharmacological activity of ofloxacin. Ofloxacin-loaded SLN were prepared using palmitic acid as lipid matrix and poly vinyl alcohol (PVA) as emulsifier by a hot homogenization and ultrasonication method. The physicochemical characteristics of SLN were investigated by optical microscope, scanning electron micros...

The aim of this work was to produce and characterize cetyl palmitate-based solid lipid nanoparticles (SLN) containing insulin, and to evaluate the potential of these colloidal carriers for oral administration. SLN were prepared by a modified solvent emulsification-evaporation method based on a w/o/w double emulsion. The particle size, zeta potential and association efficiency of unloaded and in...

The objective of the current study was to formulate solid lipid nanoparticles of oxybenzone to enhance its sunscreening efficacy while reducing its side effects. Solid lipid nanoparticles (SLNs) of oxybenzone were prepared by the solvent diffusion method. A complete 2(4) factorial design was used to optimize preparations. The study design involves the investigation of four independent variables...

Solid Lipid Nanoparticles (SLN) have been prepared by high-pressure homogenization and optimized in order to protect ferulic acid from Ferula assa-foetida L. extract. The influence of lipid surfactant concentration on the mean particle size (Z-Ave), polydispersity index (PDI), zeta potential (ZP) SLN was analyzed. In addition, other parameters for preparation acid-loaded nanoparticles, such as ...

Nanotechnology has great potential to make an important role in prevention of cancer, detection, diagnosis, imaging and treatment. Solid lipid nanoparticles (SLNs) have been introduced as an alternative drug carrier system. Some of the features of SLN include good tolerability, site-specific targeting, stability, high drug payload, controlled drug release. Caffeic acid (CA) is a widespread phen...

Objective(s): The present study aimed to determine and compare moisturizing and occlusion effects of different solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using magnetized water and deionized water.Materials and Methods: SLN formulations were prepared using various lipids, including Tripalmitin, Compritol®, Pr...

Preparation and characterization of thermoresponsive in-situ forming poloxamer hydrogel for controlled release of Nile red-loaded solid lipid nanoparticles. Nanoparticles (NPs) are cleared rapidly from systemic circulation and do not provide sustained action in most cases. To solve this problem, this investigation introduces an erodible in-situ forming gel system as potential vehicles for prolo...

The nano drug delivery system has emerged as a novel therapeutic approach for improved efficacy of the existing molecules. Polymeric nanoparticles, lipid based nanoparticles such solid (SLNs), nanostructured carriers, conjugates, ethosomes, liposomes, and self-emulsifying systems are few carriers used delivery. Among SLNs promising in terms biocompatible carrier enhancing bioavailability, contr...

Nine types of solid lipid nanoparticle (SLN) formulations were produced using tripalmitin (TPM), glyceryl monostearate (GM) or stearic acid (SA), stabilized with lecithin S75 and polysorbate 80. Formulations were prepared presenting PI values within 0.25 to 0.30, and the physicochemical properties, stability upon storage and biocompatibility were evaluated. The average particle size ranged from...