The CNS has long been considered an immune-privileged site as tissues grafted into the CNS are not rejected as they are in other tissues (Medawar, 1948; Billingham and Boswell, 1953; Barker and Billingham, 1977). An avalanche of evidence now suggests that this privilege is not absolute, as robust immune responses can occur in the CNS during infections and autoimmune diseases such as multiple sc...

sex chromosomes, or not, and to know the time scale of any degeneration, which should help us to understand the processes involved. What do you think of the growing interest in theoretical approaches to biology? Population genetics has always had a large and integral theoretical component, so I think it is very welcome that there is a growing awareness of the value of theory and mathematical mo...

The CNS has long been considered an immune-privileged site as tissues grafted into the CNS are not rejected as they are in other tissues (Medawar, 1948; Billingham and Boswell, 1953; Barker and Billingham, 1977). An avalanche of evidence now suggests that this privilege is not absolute, as robust immune responses can occur in the CNS during infections and autoimmune diseases such as multiple sc...