Hereditary spastic paraplegias and related genetically heterogeneous disorders may be difficult to distinguish clinically. The FA2H gene has been associated with autosomal recessive neurodegenerative phenotypes encompassing spastic paraplegia with or without dystonia, and demyelinating leukodystrophy. To date, few individuals with mutations in the FA2H gene have been described. We report a 5-ye...

[Purpose] The purpose of this study was to determine the differences in spatiotemporal gait parameters between children with spastic diplegic CP and children with normal development (ND). [Subjects and Methods] Sixteen children (eight children with spastic diplegic CP and eight ND children) were recruited for participation as volunteers in this study. The children with CP had a Gross Motor Func...

Cerebral palsy is a term used for a group of nonprogressive, incurable brain disorders that affect motor control. There are four different types―spastic, dyskinetic/athetoid, ataxic, and mixed―with spastic being the most common. The main symptom of spastic cerebral palsy is stiff muscles. The subtypes are categorized by the number of limbs affected and the quality of movement. The affected limb...

Similar reports in the past pay less attention to anesthetic management of these patients. We reported a 46-year-old man who suffered from hypertensive cerebral apoplexy 5 months ago and accepted C7 nerve transfer improve central spastic paralysis right upper limb. After careful evaluation anesthesia before anesthesia, operation was successfully completed under general anesthesia. The patient c...

Hereditary spastic paraplegias are inherited neurological disorders characterized by progressive lower-limb spasticity and weakness. Although more than 50 genetic loci are known [spastic gait (SPG)1 to -57], over half of hereditary spastic paraplegia cases are caused by pathogenic mutations in four genes encoding proteins that function in tubular endoplasmic reticulum (ER) network formation: at...

This investigation quantified maximum active resultant joint torques in children with spastic diplegia cerebral palsy and nondisabled children. An isokinetic dynamometer rotated the limb (10°/s) while the resultant knee joint torques (both assistive and resistive) during knee extension and flexion in 6 nondisabled children and 26 children with cerebral palsy were recorded. Torque–angle data wer...

[Purpose] To investigate the effects of progressive functional training on lower limb muscle architecture and motor function of children with spastic cerebral palsy (CP). [Subjects] The subjects of this study were 26 children with spastic CP. [Methods] Thirteen subjects in the experimental group performed general neurodevelopmental treatment (NDT) and additional progressive functional trainings...

[Purpose] The aim of this study was to investigate differences in selective voluntary motor control of the lower extremities by objective assessment and determine the relationship between selective voluntary motor control and knee extensor strength in children with spastic diplegia. [Subjects and Methods] Forty individuals who had spastic cerebral palsy, with Gross Motor Function Classification...