Steady-state enzyme kinetics is a cornerstone technique of biochemistry and related sciences since it allows the characterization quantification behaviour. Enzyme widely used to investigate physiological role enzymes, determine effects mutations characterize inhibitors. Well-known examples inhibitors treat diseases include anti-infectives (e.g., penicillin, clavulanic acid HIV protease inhibito...

sickle cell disease is a genetic haemoglobinopathy with consequent haemolysis and anaemia. it is of interest to study its effect on red cell indices beside haemoglobin concentration.the objective of the study is to determine the values of red cell indices in preschool-age children with sickle cell anaemia.we conducted a cross-sectional study including 97 children with sickle cell anaemia aged s...

background: sickle cell disease is a genetic disorder of hemoglobin causing myriad of pathology including anemia. the purpose of this study was to evaluate the baseline values of steady state hemoglobin and packed cell volume as a guide to managing the early recognition of hemolytic crises in sickle cell anemia. methods: a cross-sectional study was conducted among the sickle cell patients atten...

This paper studies the nonlinear vibration analysis of a simply supported Euler-Bernoulli beam resting on a nonlinear elastic foundation under compressive axial load using nonlinear normal modes concept in the case of three-to-one (3:1) internal resonance. The beam’s governing nonlinear PDE of motion and also its boundary conditions are derived and then solved using the method of Multiple Time ...

In this paper, we studied and formulated the relapsed SIR model of a constant size population with standard incidence rate. Also, the optimal control problem with treatment and vaccination as controls, subject to the model is formulated. The analysis carried out on the model, clearly showed that the infection free steady state is globally asymptotically stable if the bas...

We propose a thermodynamic formalism that is expected to apply to a large class of nonequilibrium steady states including a heat conducting fluid, a sheared fluid, and an electrically conducting fluid. We call our theory steady state thermodynamics (SST) after Oono and Paniconi’s original proposal. The construction of SST is based on a careful examination of how the basic notions in thermodynam...

This paper provides a briefdescription ofthe rationale behind steady-state modelling, and ofthe implementation ofthe ECOPATH II software system, a system for straightforward construction, parametrization, and balancing of steady-state trophic models of(aquatic) ecosystems. ECOPATH II is written for MS DOS computers and is available as a public domain software from the ICLARM Software Project. E...