Background Adjuvant radiotherapy (RT) after surgical resection of World Health Organization (WHO) grade II meningioma, also known as atypical meningioma (AM), is a topic of controversy. The purpose of this study is to compare overall survival (OS) with or without adjuvant RT after subtotal resection (STR) or gross total resection (GTR) in AM patients diagnosed according to the 2007 WHO classifi...

Although recent studies suggest that hyperlipidemia is a risk factor for osteoarthritis (OA), the link between OA and hyperlipidemia is not fully understood. As the number of activated, circulating myeloid cells is increased during hyperlipidemia, we speculate that myeloid cells contribute to the pathology of OA. Here, we characterized myeloid cells in STR/Ort mice, a murine osteoarthritis mode...

An error model for protein quantification: Supplementary information C. Kreutz a,b,†∗ , M. M. Bartolome Rodriguez c,†, T. Maiwald a,b, M. Seidl c, H. E. Blum c, L. Mohr c, J. Timmer a,b Freiburg Center for Data Analysis and Modeling FDM, Eckerstr. 1, D-79104 Freiburg, Germany, Department for Physics, University of Freiburg, Hermann-Herder-Str. 3, D-79104 Freiburg, Germany Department of Medicine...

Let $D$ be a finite and simple digraph with vertex set $V(D)$‎.‎A signed total Roman $k$-dominating function (STR$k$DF) on‎‎$D$ is a function $f:V(D)rightarrow{-1‎, ‎1‎, ‎2}$ satisfying the conditions‎‎that (i) $sum_{xin N^{-}(v)}f(x)ge k$ for each‎‎$vin V(D)$‎, ‎where $N^{-}(v)$ consists of all vertices of $D$ from‎‎which arcs go into $v$‎, ‎and (ii) every vertex $u$ for which‎‎$f(u)=-1$ has a...

BACKGROUND Efavirenz (EFV) administration is still controversial for its high rates of interruption mainly related to central nervous system side effects (CNS-SE). Aim of the study was to define if single tablet regimen (STR) as compared to bis-in-die (BID) or once-daily (OD) with ≥2 pills-a-day EFV formulations reduced the risk of interruption. METHODS Patients starting any cART regimen incl...

The analysis and profiling of short tandem repeat (STR) loci is routinely used in forensic genetics. Current methods to investigate STR loci, including PCR-based standard fragment analyses and capillary electrophoresis, only provide amplicon lengths that are used to estimate the number of STR repeat units. These methods do not allow for the full resolution of STR base composition that sequencin...

The curing activities of various durations of treatment with a combination of rifampin (RIF) and either streptomycin (STR) or amikacin (AMK) in murine Mycobacterium ulcerans infection were compared in two experiments. In the first experiment, treatment was begun 1 week after infection, when the inflammatory footpad lesion had not yet occurred (preventive model), and in the second experiment, tr...

BACKGROUND treatment of Mycobacterium ulcerans disease, or Buruli ulcer (BU), has shifted from surgery to treatment with streptomycin(STR)+rifampin(RIF) since 2004 based on studies in a mouse model and clinical trials. We tested two entirely oral regimens for BU treatment, rifampin(RIF)+clarithromycin(CLR) and rifapentine(RPT)+clarithromycin(CLR) in the mouse model. METHODOLOGY/PRINCIPAL FIND...

This paper presents a numerical analysis for complex 3D simulations of the Stirred Tank Reactor (STR) model by a modified discrete projection method (DPM) for rotating incompressible flow. For several prototypical configurations of the STR model, we examine the multigrid behaviour for the arising momentum and pressure Poisson subproblems for different values of the time step, the angular veloci...