نتایج جستجو برای: sustained virological response

تعداد نتایج: 1045619  

Journal: :Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 2005
C C Vere Carmen Avrămescu L Mogoantă I Rogoveanu S Cazacu T Ciurea

Hepatitis C virus infection can cause progressive liver injury and lead to fibrosis and eventually cirrhosis. Peginterferon alfa-2a represents a significant advance in the treatment of patients with chronic hepatitis C. The aim of the study was to investigate the efficacy, safety and tolerability of the therapy with Peginterferon alfa-2a plus Ribavirin in patients with chronic hepatitis C. The ...

2015
Frédégonde About Tiphaine Oudot-Mellakh Jonathan Niay Pascaline Rabiéga Vincent Pedergnana Darragh Duffy Philippe Sultanik Carole Cagnot Fabrice Carrat Patrick Marcellin Fabien Zoulim Dominique Larrey Christophe Hézode Hélène Fontaine Jean-Pierre Bronowicki Stanislas Pol Matthew L. Albert Ioannis Theodorou Aurélie Cobat Laurent Abel Chen-Hua Liu

BACKGROUND Human genetic factors influence the outcome of pegylated interferon and ribavirin hepatitis C therapy. We explored the role of IL28B, APOH and ITPA SNPs on the outcomes of triple therapy including telaprevir or boceprevir in patients with compensated cirrhosis chronically infected with HCV-1. PATIENTS AND METHODS A total of 256 HCV-1 Caucasian treatment-experienced patients with co...

2014
Alessandra Mangia Giovanni Cenderello Alessandra Orlandini Valeria Piazzolla Antonio Picciotto Massimo Zuin Alessia Ciancio Giuseppina Brancaccio Paolo Forte Vito Carretta Anna Linda Zignego Nicola Minerva Gaetano Brindicci Massimo Marignani Gianluca Svegliati Baroni Gaetano Bertino Giuseppe Cuccorese Leonardo Mottola Maria Ripoli Mario Pirisi Giovanni Li Volti

BACKGROUND Triple therapy including Telaprevir or Boceprevir still represents in many European countries the standard of care for patients with Hepatitis C Virus genotype 1 infection. The number of patients who received this treatment resulted generally lower than expected. We investigated, among naïve patients, number and characteristics of treatment candidates who were started on triple or du...

Journal: :Arquivos de gastroenterologia 2015
Maria de Lourdes Albuquerque de Queiroga Raymundo Paraná José Eymard Moraes de Medeiros Filho Giovannini Cesar A Figueiredo Ananda Peixoto de Araújo Hagley Walson Soares Leite Itiel de Souza Aquino Leonardo Honório de A Melo Neto

BACKGROUND The standard treatment of chronic hepatitis C is the administration of pegylated interferon α2a or α2b in combination with ribavirin, but adverse effects can be observed, as well as the high cost of this therapy. Therefore, there is interest in understanding the predictors of sustained virologic response, as the gamma glutamyltransferase. OBJECTIVE To evaluate the serum levels of g...

2016
Dong-Ying Xie Shi-Ming Wang Jing-Min Yang Liang-Hui Wang Hong-Yan Chen Cong Huai Jia Shang Qing Mao Chun-Liang Lei Guang-Han Luo Ji Qian Da-Ru Lu

AIM To investigate the association between interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) polymorphisms and interferon-α (IFNα) treatment efficiency among Chinese hepatitis B virus (HBV) infection patients. METHODS Two hundred and twenty five newly diagnosed chronic hepatitis B (CHB) patients were enrolled in the study. All of these patients received IFNα treatment for a ...

Journal: :The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2006
E Parise H Cheinquer D Crespo A Meirelles A Martinelli H Sette J Gallizi R Silva C Lacet E Correa H Cotrim J Fonseca R Paraná V Spinelli W Amorim F Tatsch M Pessoa

Peginterferon alfa plus ribavirin is currently the treatment of choice for chronic hepatitis C. Peginterferon alfa-2a (40KD) plus ribavirin has given an overall sustained virological response of 18% in F3/F4 previous nonresponder US patients. We evaluated the effectiveness of peginterferon alfa-2a (40KD) plus ribavirin in Brazilian patients who were relapsers or nonresponders to previous interf...

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