The testis has long enjoyed a reputation as an immunologically privileged site based on its ability to protect auto-antigenic germ cells and provide an optimal environment for the extended survival of transplanted allo- or xeno-grafts. Exploration of the role of anatomical, physiological, immunological and cellular components in testis immune privilege revealed that the tolerogenic environment ...

Xanthogranulomatous epididymitis is a rare benign process with destruction of tissue and replacement by cellular infiltration foamy macrophages, dense lymphocytes plasma cells. Literature has very few case reports. We reported here 72 years old male who presented as scrotal abscess bilateral hydrocele on ultrasound. On exploration he had normal right testis localized to epididymis underwent epi...

Objective(s): Here, we examined the function of our produced monoclonal antibody (mAb10C3) to recognize one of the most important members of the HEAT shock factor family, Hsf5, in embryonic development and in spermatogenic cells of adult mouse testis.Materials and Methods: The targeting effects of mAb10C3 were investigated by immunohisto...

This study was designed to determine the testicular abnormalities in rams slaughtered Sokoto, Nigeria. The testicles of presented for slaughter were examined, and age, breed, position, sites noted. Out 638 3 had abnormalities, representing a prevalence 0.47%, comprising 2 (0.31%) unilateral cryptorchidism 1 (0.16%) hypoplasia. (0.58% (2/342) 0.34% (1/296) obtained at Sokoto metropolitan abattoi...

background: most studies on anabolic-androgenic steroids abuse have been done in adult rats, but few data are available to immature. objective: this study was conducted to assay the effect of nandrolone decanoate (nd) on the testis and testosterone concentration in male immature rats compare with mature ones in short and long time. materials and methods: 40 mature rats were divided into 4 group...

Changes in Sertoli cell numbers and testicular structure during normal development and compensatory hypertrophy were assessed in crossbred Meishan x White Composite males. Boars were assigned at birth to unilateral castration at 1, 10, 56, or 112 days or to remain as intact controls through 220 days. The first testes removed were compared to assess testicular development. At 220 days, testicula...

background: spermatogonial stem cells (sscs), a subset of undifferentiated type a spermatogonia, are the foundation of complex process of spermatogenesis and could be propagated in vitro culture conditions for long time for germ cell transplantation and fertility preservation. objective: the aim of this study was in vitro propagation of human spermatogonial stem cells (sscs) and improvement of ...

The ultrastructure and developmental fate of the fetal generation of Leydig cells of the rat testis was studied from the 17th day of fetal life up to 100 days after birth. The number of fetal Leydig cells per testis was determined by light microscopic morphometric analysis of semithin plastic sections. In fetal testes (days 17-22 postconception), Leydig cells exhibited a characteristic ultrastr...

Sertoli cells play a significant role in regulating fetal testis compartmentalization to generate testis cords and interstitium during development. The Sertoli cell Wilms' tumor 1 (Wt1) gene, which encodes ~24 zinc finger-containing transcription factors, is known to play a crucial role in fetal testis cord assembly and maintenance. However, whether Wt1 regulates fetal testis compartmentalizati...