phage-displayed random peptide libraries (rpl) provide a powerful technique for identification, structural and functional analysis of ligands for many different target molecules, including, antibodies, receptors or other proteins. this strategy has been verified to be an effective tool for research in immunology and successfully has been used to determine the target sequence for monoclonal and ...

Background: The production of recombinant proteins in Escherichia coli is one of the most valuable achievements in biotechnology, with many therapeutic and diagnostic applications; however, the aggregation and misfolding of proteins that result in the formation of insoluble inclusion bodies is a disruptive factor in this process. Various solubilization and refolding methods can be used to impro...

There are many challenges in the field of public health sciences. Rational decisions are required in order to treat different diseases, gain knowledge and wealth regarding research, and produce biological or synthetic products. Various advances in the basic laboratory science, computer science, and the engineering of biological production processes can help solve the occurring problems. Bioinfo...

Nature has developed a plethora of protein machinery to operate and maintain nearly every task cellular life. These processes are tightly regulated via post-expression modifications—transformations that modulate intracellular synthesis, folding, activation. Methods prepare homogeneously precisely modified proteins essential probe their function design new bioactive modalities. Synthetic chemist...

Objective(s): The periodic binding of protein expressed by Mycobacterium tuberculosis H37Rv with the host cell receptor molecules i.e. fibronectin (Fn) is gaining significance because of its adhesive properties.  The genome sequencing of M. tuberculosis H37Rv revealed that the proline-glutamic (PE) proteins contain polymorphic GC-rich repetitive sequences (PGRS) which have clinical importance i...

Gastric cancer (GC) is one of the leading causes of cancer mortality, worldwide. Molecular understanding of GC’s different subtypes is still dismal and it is necessary to develop new subtype-specific diagnostic and therapeutic approaches. Therefore developing comprehensive research in this area is demanding to have a deeper insight into molecular processes, underlying these subtypes. In this st...

Medical application of ionizing radiation and radioactive isotopes were considered almost immediately after their discovery. The intense research interest in radioactivity, materials structure, subatomic particles and in the establishment of physical principles resulted in milestone inventions such as the radiotracer principle, particle accelerators, nuclear reactors and detectors sensitive eno...

Therapeutic Technic.-By Albert iS. Morrow, m.d. Third iidition. Octavo, 894 pages and 892 illustrations. W. B. Saunders Company. Price 40.?. net. This book contains a vast amount of material in an attractive form. It is thoroughly up to date and the information is given in clear and simple language. The book does not deal with the laboratory examination of material but only with the methods tha...

great value to the general practitioner, inasmuch as it brings within his reach descriptions of methods which are only to be found in monographs or recent literature. The subjects dealt with range from giving a hypodermic injection to catheterisation of the ureters, and while some of the diagnostic methods described belong more to the domain of the specialist, the majority are quite within the ...