The human monocytic leukemia cell line, THP-1, shares many properties with human monocyte-derived macrophages and might be a useful model for studying foam cell formation in vitro. Therefore, we examined the ability of THP-1 cells to accumulate cholesteryl esters, the hallmark feature of foam cells, in response to culture with native low density lipoprotein (LDL), modified LDL, and platelets. T...

Tamm-Horsfall protein (THP) is expressed exclusively in the kidney and constitutes the most abundant protein in urine. An important role for THP in antibacterial host defense but also in inflammatory disorders of the urogenital tract has been suggested. In line with this, THP has been shown recently to potently activate macrophages and dendritic cells (DC) via the toll-like receptor 4 (TLR4) pa...

Progesterone is the predominant gestagen in most mammals studied so far. It plays a substantial role regulation of female reproductive cycle and providing support for pregnancy maintenance. Despite its known functions, gaps knowledge are present regarding reduced metabolites that potentially exert biological activity. Therefore, new UHPLC-HRMS method based on Q Exactive™ mass spectrometer was d...

Objective(s): Current acute myeloid leukemia (AML) therapeutic strategies have irreversible side-effects. Berberine (BBR) is an isoquinoline alkaloid, which has been known as an aryl hydrocarbon receptor (AhR) ligand. AhR is a cytoplasmic receptor, which is involved in the regulation of cellular and immune responses. Here, we investigated the expression profile of genes involved in the cell cyc...

Exposure to nanoparticles (NPs) may cause vascular effects including endothelial dysfunction and foam cell formation, with oxidative stress and inflammation as supposed central mechanisms. We investigated oxidative stress, endothelial dysfunction and lipid accumulation caused by nano-sized carbon black (CB) exposure in cultured human umbilical vein endothelial cells (HUVECs), THP-1 (monocytes) ...

Previously, we prepared a pirarubicin (THP)-encapsulated micellar drug using styrene-maleic acid copolymer (SMA) as the drug carrier, in which active THP was non-covalently encapsulated. We have now developed covalently conjugated SMA-THP (SMA-THP conjugate) for further investigation toward clinical development, because covalently linked polymer-drug conjugates are known to be more stable in ci...

In order to solve the problem of frequent drug dosing and increase its effectiveness, theophylline (THP) was deposited on chitosan nanoparticles (CSNPs). THP-CSNPs nanocomposites with composition 50, 75, 100 or 150 mg (CS) 25, 200 tripolyphosphate (TPP) at pH 4.0, 5.0, 6.0 6.5 were prepared, a constant weight THP mg. The characterized by X-ray diffraction (PXRD), field emission scanning electro...

Tamm-Horsfall glycoprotein (THP) is expressed exclusively in the kidney and constitutes the most abundant protein in mammalian urine. A critical role for THP in antibacterial host defense and inflammatory disorders of the urogenital tract has been suggested. We demonstrate that THP activates myeloid DCs via Toll-like receptor-4 (TLR4) to acquire a fully mature DC phenotype. THP triggers typical...

The use of the tetrahydropyranyl (Thp) group for the protection of serine and threonine side-chain hydroxyl groups in solid-phase peptide synthesis has not been widely investigated. Ser/Thr side-chain hydroxyl protection with this acid-labile and non-aromatic moiety is presented here. Although Thp reacts with free carboxylic acids, it can be concluded that to introduce Thp ethers at the hydroxy...

This paper provides upper and lower bounds on the information rates achievable with a minimum mean square error (MMSE) Tomlinson-Harashima precoder (THP) assuming ideal interleaving. We also give an exact formula for zero-forcing (ZF) THP achievable information rates. At high SNR, the performance of the MMSE-THP and the ZF-THP identically suuer only the 2.55 bit or 1.53 dB \shaping" loss from c...