Scope of Translational Medicine is to speed the development of new compounds of medical protocols and/or treatments to improve patient's quality of life. Translational medicine represents the synergy between epidemiology, basic research and clinical trials, and is based upon Innovation Management and Research Development in medicine. Being the speed and progression up to the patient a key issue...

The rate of new drug approvals in the US has remained essentially constant since 1950, while the costs of drug development have soared. Many commentators question the sustainability of the current model of drug development, in which large pharmaceutical companies incur markedly escalating costs to deliver the same number of products to market. This Issue Brief summarizes the problem, describes ...

According to the World Health Organization, 1 in every 4 people develops a mental disorder. However, despite the huge efforts in the field, our knowledge about the basic mechanisms of mental disorders is still limited. Although psychiatric medications have been widely prescribed for the past decade, the low efficacy of the treatments, the lack of new validated targets or absence of robust anima...

There is growing evidence to the importance of translational science and medicine in the improvement of patient outcome, even though the definitions of translational science, translational medicine, and clinical and translational medicine need to be further clarified. In the present perspective, we collected commentaries and descriptions about clinical and translational medicine from some membe...

A discovery, synthesis and therapeutic application of cortisone present a paradigm for modern translational medicine (Hillier 2007, Saenger 2010), since they represented a joint achievement of discoveries by biochemists, Edward Calvin Kendall and Tadeus Reichstein; large scale synthesis by an industrial chemist, Lewis Hastings Sarett, and therapeutic application by a rheumatologist, Philip Show...

The hurtful feelings associated with failing can be devastating especially if the failure occurs after the investment of a considerable effort. The reflection of a lifetime of work in translational medicine has revealed that the study of failures can give birth to new insights that can be explored with important consequences. This article discusses the analysis of two failures that have led to ...

Recently, we had a well-moderated, multidisciplinary discussion on perspectives of translational medicine including experts from both the United States and China through the WeChat group for Translational Perioperative and Pain Medicine (TPPM) hosted by Dr Renyu Liu, the interim Editor-in-Chief of TPPM. This proved to be an effective approach in promoting international academic exchanges and di...

Translational research incorporates some of the oldest knowledge that the human race has gathered, from healing practices of ancient civilizations to the development of modern medicine. Today’s translational research is generally defined as the investigation that transforms scientific discoveries arising in the laboratory, clinic, or population into new clinical tools and applications that redu...