Case Report A 78-year-old Indian man presented to us with a moderate depressive episode for 1 month. He had two previous episodes of depression which occurred 45 and 20 years ago, respectively. Both the episodes fully resolved with treatment, and the patient had no residual depressive symptoms in between the episodes. He also had severe nicotine dependence (smokeless tobacco) for about 56 years...

Phenothiazines have been reported for anti-mycobacterial activity by inhibiting calcium binding proteins, potassium transport processes of phagolysosomes, NADH dependent oxygen consumption by M. tuberculosis membranes and DNA, and lipid synthesis of the bacterium. Thioridazine (TZ), chloropromazine (CPZ) and trifluoperazine (TFP) belong to the class of phenothiazines widely used as neuroleptic ...

Resistance to the cytotoxic effects of daunomycin and Adria mycin (ADR) in sublines of Ehrlich ascites and P388 mouse tumors has been demonstrated to be due to reduced cellular accumulation and retention of drug. In this study, the effect of the calmodulin inhibitor trifluoperazine on the cellular accumula tion, retention, and cytotoxic effects of ADR in ADR-sensitive (P388/S) and ADR-resistant...

Because cancer cell invasion is a critical determinant of metastasis, targeting invasion is a viable approach to prevent metastasis. Utilizing a novel three-dimensional high-throughput invasion assay, we screened a National Cancer Institute compound library and discovered compounds demonstrating inhibitory effects on cancer cell invasion. One hit, trifluoperazine, suppresses invasion of human c...

Effects on insulin release, cyclic AMP content and protein phosphorylation of agents modifying cyclic AMP levels have been tested in intact rat islets of Langerhans. Insulin release induced by glucose was potentiated by dibutyryl cyclic AMP, glucagon, cholera toxin and 3-isobutyl-1-methylxanthine (IBMX); the calmodulin antagonist trifluoperazine reversed these potentiatory effects. Inhibition b...

The Cover Feature represents the concept of feeding pharmaceuticals into a hopper placed on top NMR magnet looking at 35Cl nuclear isotope, and molecular conformations for promethazine, duloxetine trifluoperazine, as studied in paper, coming out bottom, set snowy wintry background. More information can be found Research Article by Leslie P. Hughes, Steven Brown co-workers.

Skizofrenia merupakan penyakit kejiwaan yang kompleks dan pada umumnya membutuhkan pengobatan dengan antipsikotik secara berkesinambungan. Di Indonesia, skizofrenia ditanggung oleh BPJS Kesehatan. Data klaim untuk pelayanan ini, termasuk obat-obatan, telah direkam sejak dibentuknya Kesehatan tahun 2015. Penelitian terkait pola penggunaan memanfaatkan database obat-obatan dapat memberikan inform...

Safety index (S.I.) of ether, chloroform and halothane was determined in mice following premedication with chloral hydrate, phenobarbitone, diazepam and trifluoperazine given alone or in combination with atropine or hyoscine. The S.I. of ether was significantly raised by chloral hydrate and phenobarbitone when combined with atropine while trifluoperazine in combination with atropine or hyoscine...