Peptide and protein biomolecules folded into two fundamentally different conformations, either α-helical or β-sheet, carry out dissimilar biological functions. In living organisms, an secondary structure is adopted by types of proteins such as myoglobin, keratin, collagen, more. They can be found in diverse tissues muscle, bone, cartilage, etc.. Biological functions β-sheet peptide/protein stru...

The aim of this work is to investigate the effects of different force fields and temperatures on the structural character of Aβ (12-28) peptide in aqueous solution. Moreover, the structural character of Aβ (12-28) peptide is compared with other amyloid peptides (such as H1 and α-syn12 peptide). The two independent temperature replica exchange molecular dynamics (T-REMD) simulations were complet...

Diabetes melitus merupakan masalah kesehatan global dengan tingginya angka kematian akibat berbagai komplikasi yang ditimbulkannya dan diabetes tipe 2 menjadi penyebab utama seiring bertambahnya penderita obesitas. Pengembangan obat-obat anti dilakukan, untuk menemukan kandidat obat baru tidak hanya menurunkan kadar glukosa darah tetapi diharapkan memiliki efek lebih, seperti mampu merestorasi ...

Objective(s): Hepatocellular carcinoma (HCC) is one of the leading fatal neoplasms and the most common primary liver malignancy worldwide. Peptide hormone ANGPTL8 (betatrophin) may act as an important regulator in HCC development through the Wnt/β-catenin pathway. We aimed to evaluate the effects of recombinant ANGPTL8 on Wnt/β-catenin signaling in human liver carcinom...

Light-induced molecular piping of cyclic peptide nanotubes to form bent tubular structures is described. The process based on the [4+4] photocycloaddition anthracene moieties, whose structural changes derived from interdigitated flat disposition precursors corresponding cycloadduct induced geometrical modifications in packing that provokes their curvature. For this purpose, we designed a new cl...

PURPOSE Biologically uncommon D-β-aspartyl (D-β-Asp) residues have been detected in proteins from various human tissues from elderly donors and are connected with cataract, age-related macular degeneration, Alzheimer disease and UV-irradiated skin. In a previous study, we prepared a highly specific antibody against the peptide Gly-Leu-D-β-Asp-Ala-Thr-Gly-Leu-D-β-Asp-Ala-Thr-Gly-Leu-D-β-Asp-Ala-...

Abstract Lactoferrin (LF) is known to possess anti-inflammatory activity, although its mechanisms of action are not well-understood. The present study asked whether LF affects the commitment inducible regulatory T cells (Tregs). substantially promoted Foxp3 expression by mouse activated CD4+T cells, and this activity was further enhanced TGF-β1. Interestingly, blocking TGF-β with anti–TGF-β Ab ...

Enzyme inhibitory peptides with a loop structure stabilized using an antiparallel β-sheet scaffold (β-loop peptide) were obtained from a designed peptide phage library. Human dihydrofolate reductase (hDHFR) was used as the target enzyme. The obtained β-loop peptides were competitive inhibitors of hDHFR with micromolar inhibition constants and dissociation constants.