This article gives a personal view of some of the major unanswered research questions at the interface between bone and endocrinology. One of the most compelling challenges relates to the emerging relationship between bone and energy metabolism. On a clinical level, it is well established that obesity exerts a protective effect on bone mass and risk of osteoporosis, an influence which appears t...

This 63 year old white female was admitted owing to progressive swelling of the left lower extremity for the past month. The patient also complained of occasional nocturia and alternating diarrhea tnd constipation, but denied any history of chills or fever, anorexia, or recent weight loss. Pertinent past medical history included surgery for gall bladder, hemiorrhaphy, and medical treatment for ...

We introduce Synthetic Microfluidic Paper, a novel porous material for microfluidic applications that consists of an OSTE polymer that is photostructured in a well-controlled geometry of slanted and interlocked micropillars. We demonstrate the distinct benefits of Synthetic Microfluidic Paper over other porous microfluidic materials, such as nitrocellulose, traditional paper and straight microp...

o bjectives: the aim of this study was to assess the cytotoxic effects and osteogenic activity of recombinant human bone morphogenetic protein (rhbmp2) and nano-hydroxyapatite (n- ha) adjacent to mg-63 cell line. mat erials and methods: to assess cytotoxicity, the 4,5-dimethyl thiazolyl-2,5-diphenyl tetrazolium bromide (mtt) assay was used. alkaline phosphatase (alp) activity and oste- ogenic a...

After sta~ation, amoebae of the cellular slime molds secrete acrasin [l] by which they attract each other and form an aggregate that differentiates into stalk cells and spores. In a favourable environment spores germinate yielding amoebae which feed on bacteria and m~tiply. Vegetative amoebae are also sensitive to chemotactic stimuli [4,6], which differ from acrasins. They are attracted to bact...

We present a novel integration method for packaging silicon photonic sensors with polymer microfluidics, designed to be suitable for wafer-level production methods. The method addresses the previously unmet manufacturing challenges of matching the microfluidic footprint area to that of the photonics, and of robust bonding of microfluidic layers to biofunctionalized surfaces. We demonstrate the ...