Background: It appears that chronic lupoid leishmaniasis is the result of type 2 predominant T helper response to parasite and a defect in the down regulation of IL-4 production during infection. The objective of this study was to evaluate the underlying immune status in these patients and their predominant T helper activity we considered serum IgE as an indicator of TH2 activity and IL-4...

Cow’s milk allergy (CMA) is one of the most common food allergies in first years life. CMA classified as immunoglobulin E (IgE)or non-IgE-mediated reactions. IgE-mediated reactions are typically immediate onset, with symptoms manifesting within 2 hours after ingestion. However, delayed and mostly occur between 48 post exposure. This report describes a 17-year-old who presented long-standing his...

A couple of decades ago, the diagnostic search for cause blood eosinophilia concerned, mainly, three major allergic diseases (bronchial asthma, rhinitis, atopic dermatitis), or parasitic invasion. In recent years, more and complex clinical syndromes, from reactive (secondary) to eosinophilic leukemia are increasingly considered by doctors different specialties. The aim our work was present a ca...

in order to determine the normal values of total ige in children, 3270 sera were taken from 0-14 year old males and females in different parts of tehran, the capital of iran. the technique which was used to measure total ige was elisa method using monoclonal anti-ige antibody. the results of this research indicated that the lower value for ige was detected in children at birth (x=3.s3 iu/ml), w...

The link between IL-13 and bronchial hyper-responsiveness has brought this cytokine as a potential therapeutic target for asthma and allergic diseases. At the present study, we address the role of B cell derived IL-13 in the IgE and other immunoglobulin development. Antisense oligo for human IL-13 m-RNA was used to study IgE down regulation. Human B-lymphocytes were purified by positive selecti...