The apicomplexan Toxoplasma gondii (Nicolle et Manceaux, 1908) secretes a group of serine/threonine kinases from rhoptries, which play vital roles in boosting intracellular infection. rhoptry organelle protein 17 (ROP17) is one these important kinase proteins. Nevertheless, its function remains unclear. Here, we showed that ROP17 induced autophagy vitro and vivo. small intestine tissues T. tach...

background: bcl-2 is the most important anti-apoptotic regulator and bax is a pro-apoptotic protein. the status of these parameters or the ration of bcl-2 to bax is important in malignant cell fate as well as normal cells. methods: sixty-two all patients and 62 healthy sex-and age-matched controls were studied. after genotyping, the promoter region of the bax and bcl-2 genes by rflp-pcr method ...

introduction: ghrelin is an endogenous peptide that has diverse functions in the body. one of the newly recognized roles of this peptide is its antiapoptotic effect. however, this function has not been investigated in normobaric hypoxia- induced apoptosis in body organs. this study will examine the effect of ghrelin treatment on bax-bcl-2 gene expression in the kidney of chronic hypoxic rats. m...

background : biomarkers accepted for clinical use in breast cancer have low sensitivity and specificity. thus, there is a need for new markers to assist in the diagnosis, prognosis and follow-up of breast cancer patients. this study aims to investigate the diagnostic, prognostic and follow-up role of serum bcl-2, bax and p53 proteins in breast cancer patients in comparison with those of serum c...

目的： 检测结直肠腺癌组织及癌旁正常组织bcl-2、 β-catenin蛋白表达，探讨bcl-2、 β-catenin与患者的年 龄、性别、肿瘤部位、分化程度、与、浸润深度、淋巴结转移及TNM分期等临床病理参数的关系。 方法： 原发性结直 肠腺癌及对应的癌旁正常组织各62例用免疫组织化学方法检测bcl-2、 β-catenin蛋白表达情况。结果 结直肠癌组织bcl- 2、 β-catenin蛋白表达高于远切端正常黏膜， bcl-2与浸润深度、淋巴结转移及TNM分期有关（ P < 0.05）； β-catenin与 肿瘤的分化程度、淋巴结转移及TNM分期有关（ 0.05）。 结论： 结直肠腺癌组织bcl-2和β-catenin在结直肠癌组织 中高表达，且存在一定的相关性。

Introduction Background: Considering the poorly understood mechanism of lysine demethylase 1A (KDM1A) in osteosarcoma (OS), we here commence our investigation to fill blank. Material and methods Methods: Following transfection as appropriate, 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) flow cytometry assays were used determine viability apoptosis OS cells MG-63, which ge...