Biosynthesis of glycosylphosphatidylinositol and N-glycan precursor is dependent upon a mannosyl donor, dolichol phosphate-mannose (DPM). The Thy-1negative class E mutant of mouse lymphoma and Lec15 mutant Chinese hamster ovary (CHO) cells are incapable of DPM synthesis. The class E mutant is defective in the DPM1 gene which encodes a mammalian homologue of Saccharomyces cerevisiae Dpm1p that i...

Amnesiac mutant flies have an olfactory memory defect. The amn gene encodes a homolog of vertebrate pituitary adenylate cyclase-activating peptide (PACAP), and it is strongly expressed in dorsal paired medial (DPM) neurons. DPM neurons ramify throughout the mushroom bodies in the adult fly brain, and they are required for stable memory. Here, we show that DPM neuron output is only required duri...

In this paper we investigate the datapath merging problem (DPM) in reconfigurable systems. DPM is in NP-hard and it is described here in terms of a graph optimization problem. We present an Integer Programming (IP) formulation of DPM and introduce some valid inequalities for the convex hull of integer solutions. These inequalities form the basis of a branch-and-cut algorithm that we implemented...

Background Various studies have been conducted so far regarding feeding infants exclusively with natural mother milk; various factors, which may influence feeding process, are occupation of mothers, sickness of infants or mother. This study aimed to assess the relationship between maternal general health and feeding pattern of infants. Materials and Methods This cross-sectional study was done i...

In this article, we present a novel approach to IP Traceback – deterministic packet marking (DPM). DPM is based on marking all packets at ingress interfaces. DPM is scalable, simple to implement, and introduces no bandwidth and practically no processing overhead on the network equipment. It is capable of tracing thousands of simultaneous attackers during a DDoS attack. Given sufficient deployme...

The question of whether or not soil hydraulic parameters of dualpermeability models (DPM) can be properly identified by inverse analysis of preferential water flow data has not been resolved to date. We applied a DPM based on two coupled Richards’ equations to compare the performance of inverse and forward simulations of laboratory preferential flow data. Infiltration and drainage experiments w...

Though concurrent design and construction has been lauded for reducing the time of the total processes, such an approach may make projects more uncertain and complex than those where a sequential design and construction process is used. The main sources of risk are iterative cycles that result from errors and changes introduced during the execution of concurrent design and construction. Such cy...

Herpes simplex virus (HSV) thymidine kinase (TK) has been demonstrated to be important for reactivation from latency. Specifically, HSV latency-associated transcripts (LAT) are expressed during latent infection established by TK-negative (TK-) HSV mutants, but reactivation is minimal. TK- HSV, however, readily reactivated in the presence of exogenous thymidine (TdR) in explant medium [Tenser et...