background: n-acetylcysteine (nac) has been indicated against experimental seizures, but with relatively inconclusive results. this study was undertaken to evaluate whether nac exerts a dose-dependent anticonvulsant effect and to determine nac safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses. methods: following intraperitoneal (i.p.) administration of ...

orexin, mainly produced by orexin-expressing neurons in the lateral hypothalamus (lh), plays an important role in pain modulation. moreover, it is shown that the nucleus accumbens (nac) is one of the important areas involved in this modulation. orexin-1 (ox1) and orexin-2 (ox2) receptors are densely distributed in the nac. the study investigated the involvement of ox1 receptors in the nac on an...

Objective Chlorpyrifos (CPF), an organophosphate pesticide, is widely used in farms in order to preserve crops and fruits. Previous studies have shown that CPF exposure might cause chronic toxicity in male genital system. The present study investigated the protective effect of N- Acetyl Cysteine (NAC), a potent antioxidant against toxicity effect of CPF in male mice. MaterialsAndMethods in an e...

Both the yeast nascent polypeptide-associated complex (NAC) and the Hsp40/70-based chaperone system RAC-Ssb are systems tethered to the ribosome to assist cotranslational processes such as folding of nascent polypeptides. While loss of NAC does not cause phenotypic changes in yeast, the simultaneous deletion of genes coding for NAC and the chaperone Ssb (nacΔssbΔ) leads to strongly aggravated d...

PURPOSE Recent studies have suggested a novel oncogenic role of a bric-a-brac tramtrack broad complex (also known as POZ) domain gene, NAC-1, in ovarian carcinomas. The aim of this study was to clarify the functional role of NAC-1 in human cervical carcinomas. EXPERIMENTAL DESIGN NAC-1 expression in cervical cancer was assessed by immunohistochemistry, and data on clinical variables were coll...