In mammals, protein zero (P0), a neural IgCAM, is expressed solely in the peripheral nervous system where it mediates self-adhesion of Schwann cell membranes as compact myelin is generated. We show that when P0 is expressed in HeLa, a cervical carcinoma cell line, cells regain adhesion-mediated growth control, including the acquisition of contact inhibition and loss of anchorage-independent gro...

A complex of three phosphoproteins (P0, P1 and P2) constitutes the stalk region at the GTPase center of the eukaryotic large ribosomal subunit, amongst which the protein P0 plays the most crucial role. Earlier studies have shown the functional complementation of the conditional P0-null mutant of Saccharomyces cerevisiae (W303dGP0) with orthologous P0 genes from fungal and mammalian organisms, b...

Evidence is emerging that the ability of the placenta to supply nutrients to the developing fetus adapts according to fetal demand. To examine this adaptation further, we tested the hypothesis that placental maternofetal transport of calcium adapts according to fetal calcium requirements. We used a mouse model of fetal growth restriction, the placental-specific Igf2 knockout (P0) mouse, shown p...

this paper criticizes the model and the new definition for osmotic pressure given by parsafar et al. [j. sci. i. r. iran, vol. 10, no. 4, 233 (1999)]. the model is a closed system containing 1 kg of solvent plus m mole of solute at constant temperature and under pressure p0 + ? where p0 is the standard pressure and ? is the osmotic pressure of the corresponding m molal solution. while the total...

When we toss a coin there are two outcomes and if the coin is fair, the two probabilities are equal. Consider the general case where the probability of heads is p0 and hence the probability of tails is 1−p0. This is the Bernoulli distribution where there are two outcomesX ∈ {0, 1}, and P{X = 1} = f(1) = p0 and P{X = 0} = f(0) = 1− p0 (3) When p0 = 1/2 we get the uniform distribution but with Be...

The intracellular COOH-terminal domain of the glycoprotein, P0, has been proposed to be involved in the formation of the major dense line of peripheral myelin. We have addressed this hypothesis by generating and subsequently isolating a peptide fragment that contains 65 of the 69 residues of the cytoplasmic region of rat P0. This peptide, termed P0(intra), bound to artificial phospholipid vesic...

The P0 scaffold protein of the ribosomal stalk is mainly incorporated into pre-ribosomes in the cytoplasm where it replaces the assembly factor Mrt4. In analyzing the role of the P0 carboxyl terminal domain (CTD) during ribosomal stalk assembly, we found that its complete removal yields a protein that is functionally similar to Mrt4, whereas a chimeric Mrt4 containing the P0 CTD behaves more li...

A P0-matrix is a real square matrix all of whose principle minors are nonnegative. In this paper, we consider the class of P0-matrix. Our main aim is to determine which sign pattern matrices are admissible for this class of real matrices. Keywords—Sign pattern matrices, P0 matrices, graph, digraph