D-003, a mixture of high molecular weight acids, inhibits cholesterol synthesis prior to mevalonate and prevents osteoporosis induced by ovariectomy in rats, and both osteoporosis and osteonecrosis induced by corticoids in rats. The aim of this study was to investigate effects of D-003 on lipopolysaccharides-induced osteonecrosis in rabbits. Animals were randomized into 5 groups: a sham and fou...

Abstract Study question How the human embryo builds blastocyst is crucial to improve ART, as morphology of a prime determinant assess implantation potential. Summary answer An evolutionarily conserved increase in cell contractility required generate forces driving compaction, which first morphogenetic event shaping body. What known already The begins with during cells come into close contact an...

Immunotherapeutic herpes simplex virus 2 (HSV-2) vaccine efficacy depends upon the promotion of antigen-specific immune responses that inhibit reactivation or reactivated virus, thus controlling both recurrent lesions and viral shedding. In the present study, a candidate subunit vaccine, GEN-003/MM-2, was evaluated for its ability to induce a broad-spectrum immune response in mice and therapeut...

Osteonecrosis (ON) is characterized through the impairment of osseous blood flow that leads to the collapse of femur head. Corticoid-induced ON in rats and lipopolysaccharide (LPS)-induced in rabbits are useful models to assess the efficacy of potential treatments on this disease. D-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the ...

.......................................................................................................................................... 2 1 Introduction ............................................................................................................................. 5 1.1 History of Domestic Commercial Reactor Development and Licensing ......................... 5 1.1.1 ...

Surface envelopes are tight, two-sided enclosures of composite spline surfaces. This paper shows how to construct the two hulls of the enclosure so that matched triangle pairs sandwich a given nonlinear, curved surface consisting of tensor-product Bézier patches. The main cost of the hull computation are 12 transversal line-plane intersections per vertex. The width of the enclosure, i,e. the di...

Introduction The syndrome of synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) is a rare autoinflammatory syndrome, affecting essentially the adults. Osteitis with Propionibacterium Acnes reported in the literature is generally connected to the presence of a foreign body or with the SAPHO syndrome. Chronic recurrent multifocal osteomyelitis (CRMO) is a disease related to the SAPHO ...

1 Pharmaceutical Biotechnology Division, Sri Venkateswara College of Pharmacy, Etcherla, Srikakulam-532 410, INDIA 2 Pharmaceutical Biotechnology Division, A U College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, INDIA 3 Pharmaceutical Chemistry Division, Sri Venkateswara College of Pharmacy, Etcherla, Srikakulam-532 410, INDIA 4 Pharmaceutical Technology Division, A U ...