نتایج جستجو برای: 0059

تعداد نتایج: 104  

2002
GEORGE I. STEGEMAN

1047-6938/02/02/0059/5-$0015.00 © Optical Society of America One of the goals of modern nonlinear optics is the development of the ultimate fast, all-optical device in which light can be used to control light. The unique possibilities of reconfigurable circuits created in nonlinear bulk media without any fabricated optical waveguide can be achieved by employing the fundamental concept of light ...

Journal: :Bioorganic & medicinal chemistry 2008
Matthew A Jones James D Morton James M Coxon Stephen B McNabb Hannah Y-Y Lee Steven G Aitken Janna M Mehrtens Lucinda J G Robertson Axel T Neffe Shigeru Miyamoto Roy Bickerstaffe Karl Gately Jacqueline M Wood Andrew D Abell

A series of N-heterocyclic dipeptide aldehydes 4-13 have been synthesised and evaluated as inhibitors of ovine calpain 1 (o-CAPN1) and ovine calpain 2 (o-CAPN2). 5-Formyl-pyrrole 9 (IC(50) values of 290 and 25nM against o-CAPN1 and o-CAPN2, respectively) was the most potent and selective o-CAPN2 inhibitor, displaying >11-fold selectivity. The amino acid sequences of o-CAPN1 and o-CAPN2 have bee...

2014
Lai Xu

This paper develops a new semi-parametric estimation method based on an extended ICAPM dynamic model incorporating jump tails. Themodel allows for time-varying, asymmetric jumpsizedistributions and a self-exciting jump intensity process while avoiding commonly used but restrictive affine assumptions on the relationship between jump intensity andvolatility. The estimatedmodel implies that the av...

2000
A. T. BAJKOVA

The generalized maximum entropy method (GMEM) is a special modification of the standard maximum entropy method (MEM) which seeks solutions in the space of complex functions. In this work a reduced version of the GMEM intended for reconstructing real images with positive and negative values is used. As compared with the standard MEM, intended for the reconstruction of only non-negative images, t...

2018
Takashi Kumagai Chiaki Nakaseko Kaichi Nishiwaki Chikashi Yoshida Kazuteru Ohashi Naoki Takezako Hina Takano Yasuji Kouzai Tadashi Murase Kosei Matsue Satoshi Morita Junichi Sakamoto Hisashi Wakita Hisashi Sakamaki Koiti Inokuchi

Tyrosine kinase inhibitors (TKI) improve the prognosis of patients with chronic myelogenous leukemia (CML) by inducing substantial deep molecular responses (DMR); some patients have successfully discontinued TKI therapy after maintaining DMR for ≥1 year. In this cessation study, we investigated the optimal conditions for dasatinib discontinuation in patients who maintained DMR for ≥2 years. Thi...

سفید­بالک گلخانه Trialeurodes vaporariorum Westwood (Hem.: Aleyrodidae) آفتی چندین‌خوار (پلی‌فاژ) و کلیدی است که به دامنة گسترده‌ای از گیاهان آسیب وارد می‌سازد. زنبور انگلواره یا پارازیتویید (Hym.: Aphelinidae) Eretmocerus delhiensis Mani یک گونة تخمگذار تناوبی (Synovigenic) و ماده‌زا بوده که پوره‌های سفیدبالک گلخانه را انگلی (پارازیته) می‌کند. در این پژوهش شاخص‌های جمعیت‌شناختی (دموگرافی) این ...

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