objective: il18 is a cytokine that plays an important role in the t-cell-helper type 1 (th1) response and hence, plasmid-encoded il18 is considered as a potent genetic adjuvant for dna vaccine studies. in this study, a bicistronic eukaryotic plasmid capable of secreting a more stable mouse il18 (fused with fcγ2a fragment) was constructed and expression of this chimer cytokine was also assessed....

Cerebral air emboli have been implicated in the transient neurological deficits seen in patients after cardiovascular surgery. Since perfluorocarbon emulsions such as FC-43 have greater solubilities for gases compared to plasma, it was decided to investigate their potential in providing protection against transient ischemia produced by such emboli. Forty rabbits were divided into three groups o...

This new, comprehensive text published by Wiley Blackwell provides a much needed re-write on the earlier publication of 15 y ago, published just after the approval of the first Fc-fusion protein, etanercept (Enbrel). The field of therapeutic proteins, dominated by antibodies and Fc-fusion proteins, has advanced dramatically over this period, with multiple new structures and successful therapeut...

In the present study, the aim is to optimize full and half toroidal continuously variable transmission (CVT) in order to minimize the vehicle fuel consumption (FC) in ECE driving cycle. First, the model of both CVTs’ efficiency is presented. The control strategy of CVTs speed ratio based on minimizing the vehicle FC is introduced, and the algorithm of calculating the vehicle FC is shown. Afterw...

Dracocephalum moldavica L. is an annual species of Lamiacea family whose essential oil is widely used in medicinal, food, cosmetic and health industries. Drought stress is a major factor limiting plants growth and yield. The main objective of this study was to evaluate the influence of irrigation regime on essential oil content and composition of D. moldavica L. The Irrigation regimes were 100%...

We conducted a two-way selection experiment in a composite rabbit population to investigate the responses to selection for postweaning ADG and feed conversion (FC). Two generations of crossing, followed by four generations of random pair matings, preceded three generations of selection. Selection was practiced within four lines: high-feed conversion (HFC), low-feed conversion (LFC), high gain (...

Anticorrelation between the default network (DN) and dorsal attention network (DAN) is thought to be an intrinsic aspect of functional brain organization reflecting competing functions. However, the effect size of functional connectivity (FC) between the DN and DAN has yet to be established. Furthermore, the stability of anticorrelations across distinct DN subsystems, different contexts, and ti...