نتایج جستجو برای: 1 tgf
تعداد نتایج: 2770047 فیلتر نتایج به سال:
Many types of human malignant tumor have been reported to amplify transforming growth factor-beta 1 (TGF-beta 1) gene and overexpress its protein. However, little work has been done about the content of TGF-beta 1 protein in tissue and blood of patients with malignant tumors. TGF-beta 1 protein of tissue (n = 29) and serum TGF-beta 1 levels in patients with gastric carcinoma (n = 62) were compa...
Abstract Background TGF-β and its receptors play a crucial role in asthma pathogenesis, bronchial hyperreactivity, remodeling. Expression of isoforms 1–3 TGFβ cytokine is influenced by tagging polymorphisms the TGFβ1, TGFβ2 TGFβ3 gene, these SNPs may be associated with risk development severity as well other diseases. Polymorphic forms TGF-β1, TGF-β2 TGF-β3 genes regulate degree inflammation, d...
Background: Despite substantial progress in the clinical management of diabetes, diabetic nephropathy (DN) still occurs recurrently, implicating diabetes as the major underlying condition leading to the end stage renal disease. One of the main reasons is the influential role of genetic or inherited backgrounds of diabetics that are almost overlooked in daily practice. Owing to be orchestrated b...
Objective: This study was conducted to evaluate the effect of a period of high-intensity interval training (HIIT) on myocardial collagen-1 and TGF-β1 and cardiac function in post ischemia-reperfusion rats. Materials and Methods: Thirty two (32) rats were anaesthetized by thiopental sodium. Intubation and connecting to ventilator and LAD ligation after thoracotomy was conducted. The ischem...
هدف از این پژوهش بررسی بیان ژن tgf-? در مرغ¬های جوان و مسن لاین b و d آرین با باروری بالا و پایین می¬باشد. تعداد 48 قطعه مرغ 33 هفته (24 قطعه مربوط به لاین d و 24 قطعه مربوط به لاین b) در 4 تکرار که هر تکرار مشتمل بر 6 مرغ بودند، مورد استفاده قرار گرفت. این آزمایش در قالب طرح کاملاً تصادفی با آرایش فاکتوریل 2×2 شامل 2 سطح سن (جوان 33 هفته و مسن 57 هفته) و 2 سطح لاین (لاین b و d) انجام شد. از روش...
Transforming growth factor beta 1 (TGF-beta 1) switches from an inhibitor of tumor cell growth to a stimulator of growth and invasion during human colon carcinoma progression. We originally observed that metastatic colon carcinoma cells in primary culture responded to TGF-beta 1 by proliferation, whereas moderate to well-differentiated primary site colon carcinomas were growth inhibited by TGF-...
Background: To our knowledge, there is a hypothesis regardingthe association of vitiligo with other autoimmune disorders.Organ-specific autoantibodies are found more frequently in theserum of vitiligo patients. Recent studies have demonstratedthe role of alterations in serum transforming growth factor-beta(TGF-beta) released from regulatory T cells in the pathogenesisof depigmentation observed ...
Acquired drug resistance of tumor cells is frequently observed in cancer patients undergoing chemotherapy. We studied murine leukemia L1210 cells sensitive and resistant to the cytotoxic action of cisplatin and showed that cisplatin-resistant leukemia cells were also refractory to TGF 1-dependent growth inhibition and apoptosis. Addressing the question about the mechanisms responsible for the c...
Rationale In COPD, small airway fibrosis occurs due to increased extracellular matrix (ECM) deposition in and around the smooth muscle (ASM) layer. Studies of immune cells peripheral lung tissue have shown that epigenetic changes occur COPD but it is unknown whether mesenchymal are reprogrammed. Objectives Determine if ASM a unique response profibrotic cytokine transforming growth factor ?1 (TG...
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