Glycyrrhizin, a triterpenoid saponin derived from the underground parts of Glycyrrhiza plants (licorice), has several pharmacological activities and is also used worldwide as a natural sweetener. The biosynthesis of glycyrrhizin involves the initial cyclization of 2,3-oxidosqualene to the triterpene skeleton β-amyrin, followed by a series of oxidative reactions at positions C-11 and C-30, and g...

β-N-acetylhexosaminidases have great potential in applied biocatalysis owing to their ability act on a wide range of natural and modified substrates. In this work, from four Penicillium crustosum strains (PcHex) were studied. The production showed the highest enzymatic activity culture medium after 11–14 days cultivation. specific isolated purified PcHex hydrolysis 4-nitrophenyl-N-acetyl-β-D-ga...

αβα-Tripeptide that contains a cyclic β-amino acid with an eight-membered ring, a cis-2-aminocyclooct-5-enecarboxylic acid (cis-ACOE) or a cis-2-aminocyclooctanecarboxylic acid (cis-ACOC) displayed an 11/9-helical turn in the crystal state. The related α/β-peptide oligomers were shown to adopt 11/9-helical conformations in solution.

G protein-coupled receptor 54 (GPR54) is a G(q/11)-coupled 7 transmembrane-spanning receptor (7TMR). Activation of GPR54 by kisspeptin (Kp) stimulates PIP(2) hydrolysis, Ca(2+) mobilization and ERK1/2 MAPK phosphorylation. Kp and GPR54 are established regulators of the hypothalamic-pituitary-gonadal (HPG) axis and loss-of-function mutations in GPR54 are associated with an absence of puberty and...

The catecholamine, dopamine (DA), is synthesized from 3,4-dihydroxy-L-phenylalanine (L-DOPA) by aromatic L-amino acid decarboxylase (AADC). Dopamine metabolism is regulated by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT). To measure dopaminergic metabolism, we used microdialysis with radiometric detection to monitor L-[β-(11)C]DOPA metabolites in the extracellular space of th...

The potential ergogenic effect of nutritional supplements depends on their dosage and the type exercise executed. Aiming at reviewing research literature regarding sport utilized in judo order to improve performance, a search was performed following databases: Dialnet, PubMed, Scielo, Scopus SportDiscus. A total 11 articles met inclusion criteria were selected. Evidence revised indicates that s...

The Moser-Trudinger embedding has been generalized in Adimurthi and Sandeep (2007) [2] to the following weighted version: if Ω⊂Rn is bounded, ωn−1 Hn−1 measure of unit sphere, then for α>0 β∈[0,n),supu∈B1⁡∫Ωeα|u|n/(n−1)|x|β≤C⇔ααn+βn≤1, where αn=nωn−11/(n−1) B1={u∈W01,n(Ω)|∫Ω|∇u|n≤1}. We prove that supremum attained on any domain Ω. paper also fills gaps proof Lin (1996) [21], which deals with c...