Vascular endothelial growth factor (VEGF) occurs in at least five different isoforms because of alternative splicing of the gene. To investigate the roles of different VEGF isoforms in tumor blood vessel formation and tumorigenicity, the three major isoforms (VEGF(121), VEGF(165), and VEGF(189)) were overexpressed in an early-stage human melanoma cell line (WM1341B), which is VEGF-negative and ...

common lupus. BMJ 1888; 1:58–63 3 Su WP, Perniciaro C, Rogers RS III, et al. Chilblain lupus erythematosus (lupus pernio): clinical review of the Mayo Clinic experience and proposal of diagnostic criteria. Cutis 1994; 54:395–399 4 Hedrich CM, Fiebig B, Hauck FH, et al. Chilblain lupus erythematosus: a review of literature. Clin Rheumatol 2008; 27:1341 5 Richez C, Dumoulin C, Schaeverbeke T. Inf...

This paper continues the study of the relationship between electron density and carcinogenic activity for compounds related to p-dimethylaminoazobenzene (Cancer Res., 29: 1341-1344, 1969) and reports on the seven p-dimethylaminophenylazoquinolines. A relationship was found between carcinogenic activity and the pKfl of the amino nitrogen in these compounds, and in this new series a relationship ...

“The most important undertaking in science is the establishment of experimental methods”—Ivan P. Pavlov (1849— 1936). Pavlov’s statement is readily applicable to ulcer research, i.e., establishing an experimental ulcer model that resembles human ulcers is of utmost importance. Nonetheless, although easily stated, developing an experimental method can prove difficult, especially when such a meth...

Despite extensive work-on mammals there is a shortage of accurate data on the anaesthesia of birds. Those publications which exist frequently fail to supply information on the methods used to assess the depth of anaesthesia, as was emphasized by Jordan, Sanford and Wright (1960). Birds have a high metabolic rate and a specialized respiratory system and hence frequently react poorly or adversely...