IWATSUKI, N. The Effect of Thiamylal and Propanidid on the Isolated Heart Muscle in Comparison with CT 1341. Tohoku J. exp. Med ., 1973, 110 (1), 3340 Inotropic effects of thiamylal and propanidid on the contractile state of the isolated dog heart muscle were determined by means of force-velocity relations and compared with those of CT 1341, a new steroid anesthetic. All anesthetics studied pro...

IWATSUKI, N. The Effect of CT 1341, a New Steroid Anesthetic, on the Isolated Heart Muscle. Tohoku J. exp. Med., 1973, 109 (1), 69-75 A direct inotropic effect of CT 1341, a new steroid intravenous anesthetic, upon the myocardium was studied in isolated heart muscles of dogs by measurements of force-velocity relation. CT 1341 at the concentrations over 0.139 ml/100 ml caused a dose-dependent le...

Granulomatosis with polyangiitis (GPA) is a potentially lifethreatening ANCA-associated vasculitis (AAV) that typically involves the respiratory tract and the kidney. The introduction of glucocorticoid and CYC therapy in the 1960s dramatically improved the prognosis of affected patients, with 78% surviving at 5 years compared with a 1-year mortality in 80% of untreated patients [1]. No conventi...

Antibody drug conjugates are emerging as a powerful class of antitumor agents with efficacy across a range of cancers; therefore, understanding the disposition of this class of therapeutic is crucial. Reported here is a method of enriching a specific organelle (lysosome) to understand the catabolism of an anti-CD70 Ab-MCC-DM1, an antibody drug conjugate with a noncleavable linker. With such tec...

The International Mouse Phenotyping Consortium (IMPC) is a major international effort to explore the effects of knocking out 20,000 genes in the mouse. A new study by White and colleagues, published in the current issue of Disease Models & Mechanisms, demonstrates the usefulness of lacZ in situ reporter expression patterns in extending our understanding of genotype-phenotype relationships as pa...

In this article we present a new type of 1D nanostructures consisting of supported hollow ZnO nanorods (NRs) decorated with Ag nanoparticles (NPs). The 3D reconstruction by high-angle annular dark field scanning transmission electron microscopy (HAADF-STEM) electron tomography reveals that the Ag NPs are distributed along the hollow interior of the ZnO NRs. Supported and vertically aligned Ag-N...

Oxidation of low density lipoproteins is an initial step of atherogenesis that generates pro-inflammatory phospholipids, including platelet-activating factor (PAF) and its analogs. PAF is degraded by PAFacetylhydrolase (PAF-AH), a circulating enzyme having both proand anti-inflammatory activities. PAF-AH activity has been postulated to be a risk factor for coronary artery disease (CAD); however...

Antibody drug conjugates are emerging as a powerful class of antitumor agents with efficacy across a range of cancers; therefore, understanding the disposition of this class of therapeutic is crucial. Reported here is a method of enriching a specific organelle (lysosome) to understand the catabolism of an anti-CD70 Ab-MCC-DM1, an antibody drug conjugate with a noncleavable linker. With such tec...

Sclerotinia blight, caused by Sclerotinia minor Jagger, has become one of the major limiting factors in peanut (Arachis hypogaea L.) production. The objectives of this research were to evaluate the effects of plant spacing on disease incidence and severity of Sclerotinia blight in peanut research plots, to measure the level of apparent resistance at different seeding rates, and to determine whi...

Adoptive cell transfer (ACT) of ex vivo engineered autologous lymphocytes encoding high-affinity MART-1/HLA-A 0201–specific T-cell receptor (TCR)a/b chains (F5 CTL), densely infiltrate into sites of metastatic disease, mediating dramatic but partial clinical responses in patients with melanoma. We hypothesized that MART-1 downmodulation in addition to aberrant apoptotic/survival signaling could...