BACKGROUND AND PURPOSE Mexiletine (Mex), an orally effective antiarrhythmic agent used to treat ventricular arrhythmias, has also been found to be effective for myotonia and neuropathic pain. It is extensively metabolized in humans but little information exists about the pharmacodynamic properties of its metabolites. EXPERIMENTAL APPROACH To determine their contribution to the clinical activi...

to study the effect of nitrogen form and ph of nutrient solution on the uptake and concentration of fe, zn, cu and mn in roots and shoots of spinach plant, a factorial experiment was conducted with two factors including nutrient solution ph in three levels (4.5, 6.5 and 8.0) and nitrate to ammonium ratio of nutrient solution in five levels (100:0, 75:25, 50:50, 25:75 and 0:100). the experiment ...

Mixed-valent Mn/O dinuclear and polynuclear molecular compounds containing Mn are almost without exception trapped valence. Large differences between the strengths of the exchange interactions within MnMn, MnMn and MnMn pairs lead to situations where MnMn interactions, the strongest of the three mentioned and antiferromagnetic in nature, dominate the intramolecular spin alignments in trinuclear...

This paper describes a new software-efficient 256-bit hash function, FORK-256. Recently proposed attacks on MD5 and SHA-1 motivate a new hash function design. It is designed not only to have higher security but also to be faster than SHA-256. The performance of the new hash function is at least 30% better than that of SHA-256 in software. And it is secure against any known cryptographic attacks...

INTRODUCTION: Manganese (Mn) has been increasingly used as a positive MR contrast agent to study both structures and functions in the central nervous system (CNS). Several studies indicated that the brain tissues were mainly enhanced maximally in T1WI at 1 day after systemic administration of MnCl2 in rodents (1,2). However, the specific cellular fate of Mn following overexposure is not yet ful...

Introduction: Functional MRI (fMRI) techniques are useful tools for assessing changes of the brain activity. Among them, hemodynamics based fMRI reveals vascular changes coupled to neural activation whereas manganese-enhanced MRI (MEMRI) detects neuronal activation with intracellular Ca influx by using Mn as a Ca surrogate. Although the two methods are both commonly used to detect brain activat...

Three experiments wereconducted to evaluate chemical characteristics, intestinal absorption and bioavailability of manganese(Mn)from organic, inorganic and nano sources of Mn. In experiment 1, inorganic sources of Mn including Mn-sulphate and Mn-oxide, organic sources of Mn as Mn-glycinate and Mn-bioplex and FRA® easy dry Mn as a nano source of Mn were subjected to elemental analysis and solubi...

Aleaciones cristalinas desordenadas Fe50Mn25+xSn25-x, con x = -1.25, 0.0, 2.5, 5.0, 7.5, cercanas a las composiciones de Heusler-211, fueron preparadas por fusión en atmósfera inerte, subsecuentemente, sometidas recocido térmico durante 4 días 1173 K y, finalmente, enfriadas agua helada. Todas aleaciones han sido sistemáticamente analizadas mediante difracción rayos X, espectroscopias Mössbauer...