The experimental studies on the fate of salicylic acid have yielded many conflicting results. In 1856, Bertagnini (1) reported that after ingesting salicylic acid he succeeded in isolating a compound consisting of glycine and salicylic acid which he named salicyluric acid because of its analogy to hippuric acid. Later investigators who also reported finding salicyluric acid are Nencki (2), Lesn...

OBJECTIVE To evaluate maternal and neonatal plasma concentrations of acetylsalicylic acid and salicylic acid and the neonatal endogenous prostanoid formation during low-dose aspirin prophylaxis (LDA; 100 mg daily) in pregnant women. METHODS Concentrations of acetylsalicylic acid and salicylic acid in maternal plasma after at least 4 weeks of LDA (n = 14) and in umbilical cord plasma of newbor...

Aspirin's potential as a drug continues to be evaluated for the prevention of colorectal cancer (CRC). Although multiple targets for aspirin and its metabolite, salicylic acid, have been identified, no unifying mechanism has been proposed to clearly explain its chemopreventive effects. Our goal here was to investigate the ability of salicylic acid metabolites, known to be generated through cyto...

abstract in recent years some research results have appeared that exogenous salicylic acid provided significant mitigation effect against salinity induced injuries in plants. an experiment was conducted to investigate the effects of salt stress and salicylic acid on radish (raphanus sativus l.) plants. after appearing first leaves, plants were treated by salicylic acid (0.2 mm) for 3 days and n...

background: acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles and one of the most common skin diseases.the peeling method has been recently found to be effective for acne treatment. this study aimed to compare the efficacy of pyruvic acid 50% and salicylic acid 30% peeling in the treatment of mild to moderate acne. materials and methods: in a prospective single?blin...

Salicylic acid is a classic nonsteroidal anti-inflammatory drug. Although salicylic acid also induces mitochondrial injury, the mechanism of its antimitochondrial activity is not well understood. In this study, by using a one-step affinity purification scheme with salicylic acid-immobilized beads, ferrochelatase (FECH), a homodimeric enzyme involved in heme biosynthesis in mitochondria, was ide...

salicylic acid is an important organic acid in plants rhizosphere soil exuded in the phosphorus (p) deficiency condition. to study the sorption behavior of p in the presence of salicylic acid, a batch experiment was conducted with different concentrations of salicylic acid (0, 2, 5 and 10mm) and p (0- 45 mg p/l) in a calcareous soil. the results showed that application salicylic acid decreased ...

The Gram-negative bacterium Pseudomonas aeruginosa produces the phenolic siderophore pyochelin. Salicylic acid is an intermediate in the pyochelin biosynthetic pathway, and mutants blocked in salicylic acid biosynthesis (Sal-) are able to incorporate exogenously supplied salicylic acid into pyochelin. A P. aeruginosa Sal- mutant was incubated with 13 salicylic acid analogues and was found to in...