Abstract Parkinson’s disease (PD) is the second-most common neurodegenerative worldwide. Several studies have investigated PD for decades; however, exact mechanism of development remains unknown. To study PD, SH-SY5Y cells are often treated with 6-hydroxydopamine (6-OHDA) or 1-methyl-4-phenylpyridinium (MPP+) to induce PD. understand pathogenesis, we confirmed protein changes between 6-OHDA- an...