5'-deoxy-5'-hydrazinylguanosine was incorporated into the 5'-termini of RNA transcripts using T7 RNA polymerase. Transcriptions provided 5'-hydrazinyl-RNA that was readily labeled and purified. The use of fluorophore-labeled material was validated in an endoribonuclease activity assay.

The asymmetric unit of the title compound, C15H13N3O3·H2O, comprises a 4-{(E)-[2-(pyridin-4-ylcarbon-yl)hydrazinyl-idene]meth-yl}phenyl acetate mol-ecule and a solvent water mol-ecule linked by O-H⋯O and O-H⋯N hydrogen bonds from the water mol-ecule and a C-H⋯O contact from the organic mol-ecule. The compound adopts an E conformation with respect to the azomethine bond and the dihedral angle be...

The title compound, C15H12N4O, adopts an E conformation with respect to the azomethine bond and crystallizes in its hydrazinyl-idene tautomeric form. The dihedral angle between the ring systems is 15.98 (7)°. The phenol O-H group forms an intra-molecular O-H⋯N hydrogen bond. In the crystal, pairs of N-H⋯N and C-H⋯O hydrogen bonds link neighbouring mol-ecules into centrosymmetric dimers. These d...

In the title compound, C(9)H(9)N(3), the 12 non-H atoms are essentially planar (r.m.s. deviation = 0.068 Å). The maximum deviation from planarity is reflected in the torsion angle between the β-N atom of the hydrazinyl residue and the quinolinyl N atom [N-N-C-N = -12.7 (3)°]; these atoms are syn. In the crystal, supra-molecular layers in the bc plane are formed via N-H⋯N hydrogen bonds.

JALDA, therefore, would like to show inclination towards the view that the reality of the world is not a fixed entity standing out there to be measured by our pre-fabricated ‘scientific’ instruments. In line with Haghshenas’ argumentation, not only can theories and instruments shrink to ornamental entities but also they can turn into what Karl Popper calls pseudo-science, knowledge of an ‘ideol...