The endocannabinoid 2-arachidonoylglycerol (2-AG) plays a major role in many physiological processes, and its action is quickly terminated via enzymatic hydrolysis catalyzed by monoglyceride lipase (MGL). Regulating its endogenous level could offer therapeutic opportunities; however, few selective MGL inhibitors have been described so far. Here, we describe the synthesis of N-substituted maleim...

background & aim: lemon verbena (lippia citriodora h.b.k.) is a richly scented herb and has a long history as a sacred and medicinal plant. select an appropriate medium in tissue culture is a necessity for success experimental: to evaluate the effect of 10 medium of previous researches for lippia micropropagation (1- ms medium supplemented with bap (3 mgl-1) + iba (0.1 mgl-1) + activated ch...

Background & Aim: Lemon verbena (Lippia citriodora H.B.K.) is a richly scented herb and has a long history as a sacred and medicinal plant. Select an appropriate medium in tissue culture is a necessity for success Experimental: To evaluate the effect of 10 medium of previous researches for Lippia micropropagation (1- MS medium supplemented with BAP (3 mgL-1) + IBA ...

An in vitro method was developed for high frequency shoot regeneration and continuous production of Brassica napus L. in large number. The different concentrations of benzyladenine (1.5, 3.0 and 4.5 mgl and thidiazuron (0, 0.15 and 0.30 mgl) were evaluated for shoot and root regeneration using hypocotyl explants with 7, 14 and 21 days old. Shoot regeneration (SR) was affected by both benzyladen...

Individual lines of Vitis vinifera Barbera and Chardonnay were obtained by in vitro culture of axillary buds collected from phytoplasma-affected mother plants. The molecular assays did not detect the “flavescence dorée” (FD) phytoplasma in the 66 lines tested after 6-9 months of culture, while the “bois noir”-associated phytoplasma was detected in 22 out of 50 lines. Despite the observed ineffi...

C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer. In this review, we focus on the role of the macrophage galactose type C-type lectin (MGL) in the immune response against self-antigens, pathogens, and tumor associated a...

Adult-onset Still's disease (AOSD) is a multisystem inflammatory disease of unknown etiology. It is characterized by arthritis, hectic fever, transient rash and visceral lesions such as pleuropericarditis, lymphadenopathy and hepato splenomegaly. Although kidney involvement may appear in some cases of AOSD, minimal glomerular lesion (MGL) has not been described. We describe a female patient, wh...

Mrs. Gerber’s Lemma (MGL) hinges on the convexity of H(p ∗ H(u)), where H(u) is the binary entropy function. In this work, we prove thatH(p∗f(u)) is convex in u for every p ∈ [0, 1] provided H(f(u)) is convex in u, where f(u) : (a, b) → [0, 1 2 ]. Moreover, our result subsumes MGL and simplifies the original proof. We show that the generalized MGL can be applied in binary broadcast channel to s...

An easily automatable flow-injection (FI) method for the determination of total catechins is reported. The method is based on the reaction of vanillin in acid medium to yield a coloured product with maximum absorption at 500 nm. After optimisation by the univariate and multivariate approaches as required, the linear range was established (between 10 and 90 mgL and 10 and 250 mgL for white and r...

The type of interaction between tumor-associated antigens and specialized antigen-presenting cells such as dendritic cells (DCs) is critical for the type of immunity that will be generated. MUC1, a highly O-glycosylated mucin, is overexpressed and aberrantly glycosylated in several tumor histotypes. This results in the expression of tumor-associated glycoforms and in MUC1 carrying the tumor-spe...