To reduce lithium-induced nephrogenic diabetes insipidus (lithium-NDI), patients with bipolar disorder are treated with thiazide and amiloride, which are thought to induce antidiuresis by a compensatory increase in prourine uptake in proximal tubules. However, thiazides induced antidiuresis and alkalinized the urine in lithium-NDI mice lacking the sodium-chloride cotransporter, suggesting that ...

Hypoxia is the main responsible factor initiating the symptoms of acute mountain sickness (AMS) in susceptible individuals. Measures that improve oxygenation and/or hasten acclimatization like pre-treatment with acetazolamide will prevent the development of AMS. We hypothesized that pre-treatment with acetazolamide the day before arrival at high altitude would elicit improved oxygenation compar...

We describe a case of acetazolamide induced acidosis associated with the precipitation of a hyperosmolar state in a diabetic patient 6 weeks after routine phacoemulsification. While renal tubular acidosis is well reported with acetazolamide, this case suggests that a direct diuresis induced acidosis can also have significant effects, producing serious complications when acetazolamide is prescri...

Twenty-one subjects formed a trekking expedition to study the effects of acetazolamide on exercise performance and acclimatization at high altitude. Subjects were randomized to acetazolamide or placebo on a double blind basis. During ascent to and stay for 6 nights at 4846 m studies were carried out on blood gases, 2,3 diphosphoglycerate (2,3 DPG), proteinuria, exercise testing, intestinal abso...

We describe a case of acetazolamide induced acidosis associated with the precipitation of a hyperosmolar state in a diabetic patient 6 weeks after routine phacoemulsification. While renal tubular acidosis is well reported with acetazolamide, this case suggests that a direct diuresis induced acidosis can also have significant effects, producing serious complications when acetazolamide is prescri...

We describe a case of acetazolamide induced acidosis associated with the precipitation of a hyperosmolar state in a diabetic patient 6 weeks after routine phacoemulsification. While renal tubular acidosis is well reported with acetazolamide, this case suggests that a direct diuresis induced acidosis can also have significant effects, producing serious complications when acetazolamide is prescri...

We describe a case of acetazolamide induced acidosis associated with the precipitation of a hyperosmolar state in a diabetic patient 6 weeks after routine phacoemulsification. While renal tubular acidosis is well reported with acetazolamide, this case suggests that a direct diuresis induced acidosis can also have significant effects, producing serious complications when acetazolamide is prescri...

We describe a case of acetazolamide induced acidosis associated with the precipitation of a hyperosmolar state in a diabetic patient 6 weeks after routine phacoemulsification. While renal tubular acidosis is well reported with acetazolamide, this case suggests that a direct diuresis induced acidosis can also have significant effects, producing serious complications when acetazolamide is prescri...

We describe a 58-year-old female renal transplantant recipient with standard cyclosporine-based immunosuppression who developed a potentially toxic cyclosporine concentration of 265 ng/ml after having started acetazolamide for severe glaucoma. The mechanism explaining the interaction between acetazolamide and cyclosporine remains unknown, but the concomitant use of these agents is not uncommon....

The effect of altitude and acetazolamide on breath holding was studied in 20 individuals. Breath holding time was reduced progressively during ascent. There was an additional reduction in the acetazolamide group at low but not at high altitude. The initial difference between the two groups may have been related to a lower CSF pH when on acetazolamide. At high altitude the finding of similar bre...