Background/introduction While oral acetazolamide is a cornerstone of management adult and pediatric PTCS, previous studies have suggested that used in children with other conditions may influence growth. Aims methods Retrospective chart review involving single tertiary medical center. Thirty-four definite or probable PTCS were identified. Analysis was restricted to individuals from whom anthrop...

conclusions single dose of acetazolamide was associated with statistically significant decrease in shoulder pain immediately after laparoscopy. however, this effect was limited to the first postoperative hours and it failed to reduce postoperative pain of right shoulder during 24 hours after the operation. results administration of a single dose of acetazolamide did not have any statistically s...

The voltammetric behaviour of acetazolamide, the systemic carbonic anhydrase inhibitor, in the presence of some metal ions (Cu(II), Ni(II), and V(V)) were investigated using square-wave and cyclic voltammetry in physiological pH (pH 7.4). Square-wave voltammogram of acetazolamide in the absence of metal ions gave only 1 reduction peak at -1.65 V attributed to a catalytic hydrogen peak. Three re...

PURPOSE NH4Cl gavage in the neonatal rat produces a metabolic acidosis-induced retinopathy which serves as a model for retinopathy of prematurity (ROP). Acetazolamide induces a metabolic acidosis via an alternative biochemical mechanism (bicarbonate loss versus hydrogen ion load). In the present study, the following hypothesis was tested: acetazolamide-induced acidosis is associated with preret...

INTRODUCTION Acetazolamide is commonly given to chronic obstructive pulmonary disease (COPD) patients with metabolic alkalosis. Little is known of the pharmacodynamics of acetazolamide in the critically ill. We undertook the pharmacodynamic modeling of bicarbonate response to acetazolamide in COPD patients under mechanical ventilation. METHODS This observational, retrospective study included ...

Acetazolamide increases cerebral blood flow. The generalized and regional changes in blood flow after administration of acetazolamide were evaluated by the xenon-133 inhalation technique in a series of patients with subacute or chronic focal cerebral ischemia. Acetazolamide augmented interhemispheric asymmetry of cerebral blood flow in patients with unilateral occlusion of major cerebral arteri...

Acetazolamide, a carbonic anhydrase inhibitor, is used empirically in neuromuscular diseases with episodic ataxia, weakness, and myotonia, although not all of the mechanisms responsible for its therapeutic effects are understood. To elucidate whether acetazolamide acts directly on the human skeletal muscle voltage-gated chloride channel (ClC-1), which is associated with myotonia, we evaluated t...

Acetazolamide can be taken at sea level to prevent acute mountain sickness during subsequent altitude exposure. Acetazolamide causes metabolic acidosis at sea level and altitude, and increases SaO2 (arterial oxygen saturation) at altitude. The aim of the present study was to determine whether acetazolamide impairs muscle endurance at sea level but not simulated altitude (4300 m for <3 h). Six s...

Abstract Introduction Currently two leading experimental pharmacological interventions are under investigation for obstructive sleep apnea (OSA). Acetazolamide, which acts to stabilise ventilatory control, lowers the apnea-hypopnea index (AHI) by ∼38%. More recently, atomoxetine-plus-oxybutynin (“AtoOxy”), acting via improvements dilator muscle responsiveness and baseline tone, was found lower ...

1. To investigate mechanisms of extrarenal buffering in uraemic acidosis, we studied the effects of the carbonic anhydrase inhibitor, acetazolamide, in normal subjects and in patients with end-stage kidney disease on maintenance haemodialysis with virtually no urine output. 2. Acetazolamide (500 mg) was administered daily for 7 days, after pretreatment for 1 month with 1,25-dihydroxyvitamin D (...