Leflunomide is a member of the disease modifying anti-rheumatic drugs group used as a treatment modality in active rheumatoid and psoriatic arthritis. "Oral ulcers" are reported in 3-5% of leflunomide medicated rheumatoid arthritis patients with adverse events, but they are not described in detail in the literature. We present a case of an ulcer in the tongue of a rheumatoid arthritis patient m...

background: anti-ccp is a test commonly used for the diagnosis of rheumatoid arthritis. the aim of this study was to determine the diagnostic values of accp compared to anti-mcv in rheumatoid arthritis patients in north of iran. methods: the serum samples of 150 ra patients and 75 controls, with the mean age of 49.6+11.8 and 48.8+12 years respectively, were tested using the commercially availab...

background: patients with rheumatoid arthritis (ra) suffer from wide ranges of autoimmune reactions in joints. the mechanism of which is generally unknown and maybe associated with treg deregulation. objective: to compare the frequency of ntregs in peripheral blood of patients with active rheumatoid disease with healthy individuals. methods: twenty five newly diagnosed patients with active ra d...

the purpose of this study was to investigate any association between iga deficiency (igad) and juvenile rheumatoid arthritis (jra) among iranian children. this case-control study was carried out on 83 children who were diagnosed as jra according to american college of rheumatology (acr) criteria; patients were admitted at the rheumatology clinic of children's medical center, (tehran). serum imm...

objectives: foot and ankle problems are common complications in rheumatoid arthritis disease. gait pattern such as normal foot and ankle rocker is impaired in patients with rheumatoid arthritis. rocker sole as an external shoe modification is commonly prescribed in this pathology. the aim of this study was to investigate the effect of rocker shoe on vertical ground reaction force parameters dur...

rheumatoid factors (rf) are autoantibodies with specificity for the fc portion of human igg. production of rf is a characteristic feature of rheumatoid arthritis (ra) and is detectable in high titer in about 90% of these patients. in this study, we measured total igm, iga, igmrf and igarf in serum and synovial fluid of 45 ra patients by elisa and the results were compared with those obtained by...

OBJECTIVE To investigate the role of circulating hepcidin, which is a homeostatic regulator of iron metabolism and a mediator of inflammation, in anemia associated with rheumatoid arthritis. METHODS Forty patients with rheumatoid arthritis (19 with anemia and 21 without anemia), 12 patients with iron deficiency anemia and 14 healthy adults were studied. Serum hepcidin levels were analyzed wit...