background traditional medicines are among the oldest medicines and their extensive use in the recent years reflects the public’s interest in alternatives to conventional medicine. objectives the aim of this study was to investigate the genotoxicity of dillsun herbal medicine in dna damage of rat hepatocytes compared to sodium dichromate using a comet assay technique. materials and methods male...

the acute toxicity of a malaysian crude oil to red snapper, lutjanus argentimaculatus, blacktiger shrimp and penaeus monodon were investigated. the animals were exposed to water solublefractions (wsf) of crude oil in a flow-through bioassay system and the toxicants were analyzed by gaschromatography (gc) and gas chromatography and mass spectrometer (gc-ms). the 96 h lc50 valuesof the wsf of cru...

malathion is one of the most commonly used pesticides in agriculture. this study was aimed to investigate the acute toxicity of malathion as an aquatic pollutant on the behavior and hematological indices in indian carp ( cirrhinus mrigala ). a static experiment was conducted and 1, 24, 48, 72 and 96 hrs lc 50 values of malathion for the test fish were estimated as 14.55 mg/l, 12.48 mg/l, 11.56 ...

Background: Ferula species have shown wide range of pharmacological properties but there is no study on oral safety profile of Ferula persica due to standard toxicology guidelines. Objective: This study aimed to evaluate the acute and subchronic oral toxicity of the alcoholic extract of the aerial parts of Ferula persica to provide its safe dose for long term oral administrations as a possible...

Solar simulator irradiation of an aqueous suspension of prednisone, a widely prescribed drug, produces seven photochemical derivatives. The compounds have been identified on the basis of their physical features. All the chemicals have been tested to evaluate their toxic effects on freshwater organisms from different trophic levels. The rotifer Brachionus calyciflorus and two crustaceans, the cl...

Ethanolic extract of pomegranate (Punica granatum L) peel: acute toxicity tests on zebrafish (Danio rerio) embryos and its prediction by in silicoIndra Wibowo, Kurnia Permadi, Rika Hartati, Sophi Damayanti

Acute semistatic toxicity tests were carried out for 96h with first zoeae and young crabs of Chasmagnathus granulata. Survival curves and LC50 (lethal concentration 50, the concentration which produces the death of 50% of the exposed population) indices for copper, zinc, cadmium, and lead were determined. Furthermore, mixture toxicity tests (Cd/Cu and Cd/Zn) with first-stage larvae were also ca...

objective: vitex agnus-castus (vac) and its essential oil have been traditionally used to treat many conditions and symptoms such as premenstrual problems, mastalgia, inflammation, sexual dysfunction, and pain. in this study, the effects of essential oil extracted from vitex agnus-castus (eovac) leaves were investigated in three behavioral models of nociception in adult male wistar rats. materi...