نتایج جستجو برای: adad
تعداد نتایج: 72 فیلتر نتایج به سال:
OBJECTIVE To analyze the association between drug (DAD) and alcohol (AAD) abuse and dependency and criminal and clinical background by gender of prisoners in São Paulo, Brazil. METHOD Cross-sectional study, random sample stratified by administrative district, from which prisons and prisoners were selected via random, multistage sampling. Psychiatric diagnoses were made with the CIDI 2.1. Life...
Abstract Background Accelerated long-term forgetting has been identified in preclinical Alzheimer’s disease (AD) and is attributed to a selective impairment of memory consolidation which the hippocampus plays key role. As blood may contain multiple senescence-related factors that involved neurogenesis synaptic plasticity hippocampus, we tested whether there an association between blood-borne ac...
Background Cerebrospinal fluid (CSF) biomarkers have potentially important roles in Alzheimer’s disease (AD) treatment and prevention trials. The Prevention Initiative Autosomal-Dominant AD (API ADAD) trial protocol (NCT01998841) includes optional CSF biomarker measurements at baseline, 24 months, 60 months. We determined the adherence to lumbar puncture (LP) procedures predictors of dropout ra...
Abstract Background Autosomal dominant Alzheimer's Disease (ADAD) is an important area of study to understand the pathogenesis AD. Previous studies suggested that mutations in genes coding for amyloid precursor protein cause early deposition amyloid‐β peptide (Aβ), resulting amyloid‐induced inflammatory response and cortical microstructural changes during cognitively asymptomatic phase, several...
Background We have proposed astrogliosis as a “first wave” of response to AD pathology with diverging longitudinal changes reactive astrocytes and amyloid-β positron emission tomography (PET) retention in pre-symptomatic autosomal dominant (ADAD). It has been suggested that plasma glial fibrillary acidic protein (GFAP) could be marker neuroinflammation brain, although this hypothesis remains un...
BACKGROUND The causes of phenotypic heterogeneity in familial Alzheimer's disease with autosomal dominant inheritance are not well understood. We aimed to characterise clinical phenotypes and genetic associations with APP and PSEN1 mutations in symptomatic autosomal dominant familial Alzheimer's disease (ADAD). METHODS We retrospectively analysed genotypic and phenotypic data (age at symptom ...
Aneurysms of the coronary arteries are rare, and it is only after the advent of coronary arteriography that they have been diagnosed in life. They may be due to atherosclerosis, necrotizing arteritis, myocotic emboli, syphilis, or trauma, and occasionally they are congenital. The prognosis appears to be poor and death can occur suddenly from rupture, peripheral coronary embolism, or bacterial e...
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