b a c k ground: several studies have indicated that executive dysfunction is the main neuropsychological feature of parkinson’s disease (pd). the frontal assessment battery (fab) is a short tool for the assessment of executive functions. p u r p o s e : the aim of this study was to determine the relationship between persian version of fab scores and age, education, mini-mental state examination...

parkinson's disease is a degenerative disorder of the central nervous system. the motor symptoms of parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain the cause of this cell death is unknown. homocysteine (hcy) is a non-protein amino acid. it is a homologue of the amino acid cysteine. the elevated levels of homocysteine in pl...

whole body vibration (wbv) is a contemporary treatment modality that holds promise as an exercise training method in health–compromised individuals. a growing number of studies on individuals with parkinson disease are examining whether wbv improves balance and functional mobility. however, interpreting wbv studies is challenging since there is variability in the manner in which wbv interventio...

Background STB DBS (deep brain stimulation of the subthalamic nucleus) is commonly used to treat advanced Parkinson disease (PD) while posterior hypothalamic DBS for cluster headache (CH) remains experimental. Methods We present a case where a middle-aged man was diagnosed with both CH and PD and received medical treatment for both. The patient was treated with bilateral STN DBS after develop...

Parkinson’s Disease (PD) is a chronic, progressive, neurodegenerative disorder with motor and non-motor signs and symptoms. PD is caused by idiopathic degeneration of dopamine-producing cells in the substantia nigra, located in the midbrain. Recently, Trace elements have been recognized to play an important role in the development of Parkinson’s disease (PD). The aim of this review ...

OBJECTIVE Brain-computer interfaces (BCIs) could potentially be used to interact with pathological brain signals to intervene and ameliorate their effects in disease states. Here, we provide proof-of-principle of this approach by using a BCI to interpret pathological brain activity in patients with advanced Parkinson disease (PD) and to use this feedback to control when therapeutic deep brain s...

Posteroventral pallidotomy as a treatment for Parkinson’s disease (PD) has been the subject of increasing interest. We treated 4 nondemented patients with advanced PD, 2 with severe bradykinesia and a declining response to medication, and 2 with marked clinical fluctuations. All patients received 180 Gy delivered in one sitting to the right posteroventral pallidum site, used by Laitinen and col...

since its first description of botulism toxicity in 1820s, specific formulations of botulinum neurotoxin (bont) have been introduced with different clinical benefits. however, there is increasing number of adverse events reported to food and drug administration. this report presents the case of 62-year-old woman with parkinson’s disease who received bont injections to treat painful spasticity i...

background: vitamin d is an important factor responsible for many physiologic functions. vitamin d deficiency is associated with increased risk of neurodegenerative disease. the level of vitamin d in iranian patients with parkinson's disease and its relationship with severity of symptoms and signs were evaluated in this study. methods: eighty-three patients with parkinson's disease (pd) were re...

introduction: one of the most common syndromes in parkinson's disease (pd) is rigidity. currently, an index is used to evaluate the level of pd by the clinical measurement of rigidity in the upper extremity. the index uses a subjective method called unified parkinson's disease rating system (updrs). the subjective nature of this method makes the influence of physician in the measureme...