Adverse drug reactions (ADRs), of which adverse interactions are a special case, are a major cause of morbidity in the community. They are also reported to account for up to 5 per cent of all medical admissions to hospital (Grahame-Smith and Aronson, 1992; Aronson and White, 1996) and they are occasionally fatal. In the USA, it has been suggested that they are between the fourth and sixth commo...

UWM-Adverse Drug Events Corpus (UWM-ADEC) is an annotated corpus that has been developed from consumer drug review posts in social media. In this corpus, we identified four types of Adverse Drug Reactions (ADRs) including physiological, psychological, cognitive, and functional problems. Additionally, we mapped the ADRs to corresponding concepts in Unified medical language Systems (UMLS). The qu...

UNLABELLED AIM The purpose of our study was to investigate and to assess the perceptions of Romanian doctors towards adverse drug reactions (ADRs) reporting. METHOD A questionnaire with 20 items accompanied by a letter presenting the study was circulated using Internet and face to face interviews to 532 doctors in Bucharest and two neighboring regions from Romania (Muntenia and Oltenia). ...

Results A total of 15,541 ADRs was reported in patients greater than or equal to 18 years. Common causative drug category included nervous system, neoplastic, anti-infectives. The prevalence of ADRs due to respiratory drugs and cardiovascular drugs was higher in the elderly group (¡Ã 60 years) than in other groups. The most prevalent clinical types were gastrointestinal disorders and skin and a...

PreAVOID, which refers to cases in pharmacists avoid or reduce undesirable drug-related issues (eg, adverse drug reactions [ADRs], drug-drug interactions, and insufficient therapeutic effects) by pharmaceutical interventions, have been used as one of the indicators pharmacists’ professional performance. In recent years, despite efforts undertaken community promote PreAVOID reports not adequatel...

Adverse drug reactions (ADRs) are caused by interactions between drugs or their metabolites and specific proteins. Knowledge of these proteins is important for facilitating mechanistic research of ADRs and new drug discovery. Here, we identified 41 network modules from an ADR-protein network; analysed the function of each module; revealed the potential accompanying actions of the ADRs and the n...

Medication errors are the second most common cause of adverse patient safety incidents and the single most common preventable cause of adverse events in medical practice. Given the high human fatalities and financial burden of medication errors for healthcare systems worldwide, reducing their occurrence is a global priority. Therefore, appropriate policies to reduce medication errors, using nat...

The current challenges in healthcare including the high costs and high rates of Adverse Drug Reactions (ADRs) call for fundamental changes in both drug development and clinical practice [1,2]. The “onesize-fits-all” drugs ignoring individual differences are often the causes of the ADRs. Paper-based and non-standardized clinical systems have also contributed to errors and adverse events. At the ...

BACKGROUND Postmarket drug safety surveillance largely depends on spontaneous reports by patients and health care providers; hence, less common adverse drug reactions--especially those caused by long-term exposure, multidrug treatments, or those specific to special populations--often elude discovery. OBJECTIVE Here we propose a low cost, fully automated method for continuous monitoring of adv...

Adverse drug reactions (ADRs), unintended and sometimes dangerous effects that a drug may have, are one of the leading causes of morbidity and mortality during medical care. To date, there is no structured machine-readable authoritative source of known ADRs. The United States Food and Drug Administration (FDA) partnered with the National Library of Medicine to create a pilot dataset containing ...