introduction treatment of severe hemorrhagic shock due to acute blood loss from traumatic injuries in a jehovah’s witness (jw) trauma patient is very challenging since hemostatic blood product resuscitation is limited by refusal of the transfusion of allogeneic blood products. case presentation we describe a multifaceted approach to the clinical care of a severely anemic jw trauma patient inclu...

BACKGROUND Cardiosphere-derived cells (CDCs) are an attractive cell type for tissue regeneration, and autologous CDCs are being tested clinically. However, autologous therapy necessitates patient-specific tissue harvesting and cell processing, with delays to therapy and possible variations in cell potency. The use of allogeneic CDCs, if safe and effective, would obviate such limitations. We com...

The surface marker profile of mesenchymal stromal cells (MSCs) suggests that they can escape detection by the immune system of an allogeneic host. This could be an optimal strategy for bone regeneration applications, where off-the-shelf cells could be implanted to heal bone defects. However, it is unknown how pre-differentiation of MSCs to an osteogenic lineage, a means of improving bone format...

background: myeloablative-allogeneic stem cell transplantation is a common way of treating various malignant and nonma-lignant diseases; but, it is associated with hazardous immediate and late complications. the majority of patients are not good candidates for high dose therapy because of old age, medical co-morbidities or previous heavy treatments. the donor stem cells can engraft in the recip...

BACKGROUND Transplantation of allogeneic mesenchymal stromal cells (MSCs) is a promising treatment for heart failure. We have shown that epicardial placement of cell sheets markedly increases donor cell survival and augments therapeutic effects compared with the current methods. Although immune rejection of intramyocardially injected allogeneic MSCs have been suggested, allogeneic MSCs transpla...

Abstract Autologous dendritic cell (DC) vaccines with tumor antigens have been used clinically limited therapeutic effects. Semi-allogeneic DC-based immunotherapy is still controversial, but it can be an alternative source and more attractive than autologous DC because the “off-the-shelf” DCs for multiple patients without lengthy individual manufacturing time may provide additional “allogeneic ...

Thoracic duct lymphocytes from rats sensitized against syngeneic spinal cord rapidly produce damage in cultures of syngeneic cerebellar cells but coexist indefintely with allogeneic cultures. Lymphocytes from donors that have been sensitized against allogeneic spinal cord attack cultures of syngeneic and specific allogeneic cerebellum but not cells from rats of a third, unrelated strain.

Allogeneic hematopoietic stem cell transplantation is a well-proven treatment for hematologic malignancies and non-malignancies, but it has high risk of disease recurrence severe transplant-related morbidity death. The mortality long-term survival post-allogeneic transplant patients are improving due to improvements in condition procedures, methods, novel medicines, supportive care practices. (...