One week of treatment with EGF and gastrin (EGF/G) was shown to restore normoglycemia and to induce islet regeneration in mice treated with the diabetogenic agent alloxan. The mechanisms underlying this regeneration are not fully understood. We performed genetic lineage tracing experiments to evaluate the contribution of beta cell neogenesis in this model. One day after alloxan administration, ...

The hypoglycaemic effect of aqueous leaf extract of Murraya koenigii was studied in normal and alloxan-induced diabetic rats. The extract was administered orally at 100 mg/Kg, 150 mg/Kg and 200 mg/Kg bodyweight each to respective groups of animals (Groups I, II and III) for seven days. Group IV received normal saline and served as control for the normal rats. For the alloxan-induced diabetic ra...

From Table 2 it will also be seen that the diabetogenic dose of alloxan in normal animals, as found in this laboratory, ranges between 130 and 140 mg./kg. and the lethal dose is observed to be in the neighbourhood of 225 mg./kg. It is interesting to note that the diabetogenic and lethal doses of alloxan in acetoacetate-treated animals, having blood GSH in the neighbourhood of 3 mg./100 ml., are...

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with longterm damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels. The present study was carried out to investigate the effects of...

PURPOSE To evaluate the effect of short and long term alloxan-induced diabetes on bladder and urethral function of female rats, and also describing its correlated morphological alterations. METHODS Thirty five female rats were divided into three groups: G1 (n=9), control group; G2 (n=17), six weeks alloxan-induced diabetic rats; G3 (n=9), 20 weeks alloxan-induced diabetic rats. Functional eva...

Diabetes mellitus has been considered as one of the major health concerns all around the world today. The newest tainted food supply concern is that flour in commonly consumed baked goods is being bleached with chloride oxide that produces alloxan as a byproduct, leading to toxic effect on Beta cells of the pancreas. This causes an insulin-dependent diabetes mellitus also called as "Alloxan Dia...

Electrolyzed reduced water, which is capable of scavenging reactive oxygen species, is attracting recent attention because it has shown improved efficacy against several types of diseases including diabetes mellitus. Alloxan produces reactive oxygen species and causes type 1 diabetes mellitus in experimental animals by irreversible oxidative damage to insulin-producing β-cells. Here, we showed ...

s Liver glycogen content and liver glycogen synthesis are lowered in diabetes mellitus due to lack of functioning insulin. Many enzymes of glycogen metabolism as well as glucose metabolism are sulfhydryl in nature and are affected by changes in cellular thiol-disulfide ratio. Certain low molecular weight thiols can influence glucose uptake and utilization in fat cells and in muscle cells. A stu...

The methanol extract of Gladiolus psittascinus bulb was evaluated for its antidiabetic activities in alloxan-induced diabetic rats. Blood glucose levels of the glucose loaded and alloxan-induced diabetic rats were estimated over 180 minutes using the O-toluidine and glucose-oxidase methods. The methanol extract at 1 g/kg dose exhibited 16.2% decrease in blood glucose level in the glucose loaded...

The antidiabetic potentials of the methanol extract of Parkia biglobosa seed (Mimosoideae), its chloroform, hexane, and mother liquor fractions were evaluated in glucose-loaded and alloxan-induced diabetic rats. The methanol extract of the seed exhibited a peak percentage decrease of 64% and 44.1% in blood glucose levels of the glucose-loaded and alloxan-induced diabetic rats respectively. The ...