The high neuroactive potential of metabolites produced by gut microbes has gained traction over the last few years, with metagenomic-based studies suggesting an important role microbiota-derived γ-aminobutyric acid (GABA) in modulating mental health. Emerging evidence revealed presence glutamate decarboxylase (GAD)-encoding gene, a key enzyme to produce GABA, prominent human intestinal genus Ba...

Background: Patients with stiff-person syndrome (SPS) have circulating antibodies against glutamic acid decarboxylase, the rate-limiting enzyme responsible for the synthesis of -aminobutyric acid (GABA). Although the patients’ symptoms of stiffness and unexpected spasms can be explained on the basis of reduced or impaired inhibitory neurotransmitters, such as GABA, it is unclear whether the lev...

γ-Aminobutyric acid (GABA) is a ubiquitous nonprotein amino that has multiple physiological functions and received significant attention in the pharmaceutical food industries. Although there are many GABA-producing bacteria, high cost of strain cultivation limits its additive raw material application. In our study, Lactobacillus hilgardii GZ2, novel strain, was investigated. We attempted to rep...

The conformational behaviour and GABA receptor activity of the different stereoisomers of 2,3-difluoro-4-aminobutyric acid are described. Two enantiomeric GABA(C)-active ligands are identified, one of which is an agonist while the other is an antagonist. The results support an existing QSAR model of the bioactive geometry of GABA at GABA(C).

Abstract. Syukur S, Safrizayanti, Zulaiha Supriwardi E, Fahmi A, Nurfadilah KK, Purwati E. 2021. Potential antioxidant activity of Lactobacillus fermentum KF7 from virgin coconut oil products in Padang, West Sumatra, Indonesia. Biodiversitas 23: 1628-1634. The isolation and characterization five commercial Virgin Coconut Oil (VCO) circulating the local market Padang city were conducted. In this...

Changes in extra and intracellular neurotransmitter amino acids concentration in the early stage of acute cerebral ischemia have been reported. In this the study, serum level of gamma aminobutyric acid (GABA) and L-Arginine in acute ischemic stroke patients was assessed. 60 patients with acute ischemic stroke and sixthy healthy volunteers as a control group were assessed. Serum GABA was measure...

Transportation of amino acids throughout the body is an essential mechanism to support life processes. phenomena such as diffusion, viscosity, etc., in aqueous medium are useful understand their inter- and intra-molecular interactions. In this work, we performed classical molecular dynamics simulation study transportation properties γ-aminobutyric acid (GABA) environment. Self-diffusion coeffic...