There are two central issues to consider in assessing the motor side effects of atypical antipsychotic (AA) drugs. The fi rst is the defi nition of what it means to be an AA drug. While one review states that ‘the defi ning characteristic of an AA is its lower risk of inducing EPS [extra pyramidal symptoms] [1]’ there is, in fact, no consensus defi nition [2] of what it means to be ‘atypical’. ...

on YouTube about using one of its products and the content prompts questions about off-label use, this would be a solicited request. The FDA may consider solicited requests evidence of a firm’s intent that a drug be used for off-label purposes. 2. The guidance also distinguishes between non-public and public unsolicited requests and recommends appropriate responses. For example, a telephone cal...

privatization is a process in which the ownership of governmental economic enterprises is transferred to private sector. according to other countries’ experiences and discussed economic theories over the past decades, privatization has improved the performance of companies and economic enterprises. in this study, financial ratios of companies were used as their performance indicators. this pape...

In November, 1963, a small private symposium met at Johns Hopkins Univers^ to explore what were the major problems in making safe and effective drugs avails. from both the academic and industrial fields were present. In addition, the gt?f. included economists, the president of a drug company, lawyers and an Eng'1^ social scientist (Professor Richard Titmuss). In the course of their deliberation...

I n global-health politics, cardiovascular disease is the elephant in the room—a massive problem that few want to acknowledge and even fewer want to tackle. In [a recent issue of] Lancet, Carlene Lawes and colleagues, on behalf of the International Society of Hypertension, estimate that bloodpressure-related diseases cause about half this burden, killing around 8 million people each year.1 Low-...

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Highlights Q The Good: Sweeping reform plan does not pass because it is too costly to be financed without huge taxes. But, healthcare disinflation continues; drug companies keep their pricing increases to CPI or CPI + 1%. Health supply/device stocks unit growth flattens, but best companies still achieve 12-15% growth. Firms withdraw from marginal businesses, trim sales forces/product lines and ...

Dr. Salk's professional life was as far removed from that oftoday's researchers at the National Institutes ofHealth as the sun is from, say, Wall Street. Theoretically, the NIH belongs to the American people. U.S. taxpayers give it $28 billion a year to develop remedies for human misery. Many assume that today's NIH researchers are carrying on the mission as Salk did, free from financial or com...

The Occasional Papers series is intended to provide a forum for examining a wide range of topics of interest to the hemophilia community. The World Federation of Hemophilia does not engage in the practice of medicine and under no circumstances recommends particular treatment for specific individuals. Dose schedules and other treatment regimes are continually revised and new side effects recogni...