background epilepsy is a chronic neurological disease with the prevalence of around one percent. despite the introductions of several anti-epileptic drugs, around 1/3 of epileptic patients are resistant to the anti-epileptic medications. objectives considering the evidence regarding the anti-oxidant action of vitamin e and its beneficiary effect in the treatment of epilepsy, we investigated the...

A close relationship exists between sleep and epilepsy. While many forms of epilepsy may be influenced by the sleep-wake cycle, this phenomenon is particularly evident in frontal lobe epilepsy where affected individuals may experience seizures exclusively during sleep (nocturnal frontal lobe epilepsy, NFLE). In this thesis, three aspects of the relationship between sleep and frontal lobe epilep...

psychiatric disorders are very prevalent in epilepsy, 30 to 50 percent of epileptic patients suffer from psychiatric problems. on the other hand, many psychiatric disorders such as dissociative disorder, sleep disorder, impulse control disorder and cyclic disorders have clinical features like epilepsy. therefore, differential dagnosis is very important in dealing with epilepsy. epilepsy has man...

Background and objectives:
 Epilepsy is a neurological disorder in which the patient suffers with two or more unprovoked seizures. It one of most common disorders worldwide, affecting than 70 million people. Currently various modes effective treatments are available, but still there many cases that remain drug resistant. Hence, need to explore herbal medications for treatment resistant epi...

Background and Objective: Temporal lobe epilepsy (TLE) is a chronic neurological disorder with spontaneous recurrent seizures and abnormal intracranial waves. Since the role of oxidative stress in the occurrence of epilepsy is inevitable, it seems that the use of antioxidants can prevent some of the complications resulting from this disease. This study was designed to assess the protective effe...

introduction: kainic acid (ka) induces neuropathological changes in specific regions of the mouse hippocampus comparable to changes seen in patients with chronic temporal lobe epilepsy (tle). according to different studies, the expression of a number of genes are altered in the adult rat hippocampus after status epilepticus (se) induced by ka. this study aimed to quantitatively evaluate changes...

background: this study compares the clinical characteristics of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mtle-hs) with those who have temporal lobe epilepsy (tle) due to other etiologies.   methods : in this retrospective study all patients with a clinical diagnosis of tle were recruited in a referral outpatient epilepsy clinic at shiraz university of medical scie...

Mesial temporal lobe epilepsy (MTLE) is one of the most common types focal in adult population. MTLE frequently associated with a specific histopathological lesion medial structures, namely hippocampal sclerosis (HS). A significant proportion patients MTLE+HS have severe epilepsy, which often resistant to clinical treatment. For these patients, surgical resection epileptogenic can be performed....

AIM Comprising large areas of association cortex, the parietal lobe is part of an extensive synaptic network elaborately intertwined with other brain regions. We hypothesize that such widespread projections are responsible for producing inaccurate localisation readings on scalp EEG and clinical semiology in patients with parietal lobe epilepsies, as opposed to frontal or temporal lobe epilepsie...