during a period of 10 months from may to february 1995, 120 children (72 girls, 48 boys) with an age range of 4-16 years (mean age 10.87, s.d.±2.7) with chronic abdominal pain who had an abnormal endoscopy (gastroduodenal mucosal defect) and positive urease test were treated for h. pylori. patients were treated randomly with either metronidazole and amoxicillin (double therapy, group a) or metr...

systemic antibiotics and locally applied antimicrobial agents have been suggested to enhance clinical parameters. patients exhibiting aggressive periodontitis in particular benefit from adjunctive antibiotic therapy. the purpose of this investigation was to evaluate the effect of local antibiotic therapy with metronidazole adjunctively to scaling and root planning (srp) in the treatment of aggr...

ANTIBIOTICS Fluoroquinolones The fluoroquinolone class of antibiotics work via inhibition of DNA gyrase (topoisomerase II). Resistance is mediated through chromosomal mutations in DNA gyrase which confers cross-resistance to other FQs. FQs distribute well to tissues and intracellularly. Elimination is via the kidney, and these drugs are often highly effective for treating resistant UTIs. The sp...

OBJECTIVE To investigate the clinical usefulness of procalcitonin (PCT) for guiding duration of antibiotic therapy in patients with severe acute pancreatitis (SAP). METHODS A total of 71 patients with confirmed severe acute pancreatitis from March 2009 to September 2011 in the Department of Critical Care Medicine of Huizhou Municipal Central Hospital, Guangdong, China were enrolled in this st...

Clindamycin is a lincosamide antibiotic which is approved for the treatment of anaerobic, streptococcal and staphylococcal infections. There has been an increased interest in the use of clindamycin since it achieves high intracellular levels in phagocytic cells, high levels in bone and appears to have an antitoxin effect against the toxin elaborating strains of streptococci and staphylococci. C...

conclusions physicians are recommended to take microbiological cultures before starting empirical therapy recommended to cover gram-negative microorganisms in order to lower the risk of antibiotic resistance. objectives the current study aimed to determine the most common microorganisms involved in diabetic foot infection in order to minimize the failure of antibiotic therapy and the risk of de...

The standard recommendation for treating chronic osteomyelitis is 6 weeks of parenteral antibiotic therapy. However, oral antibiotics are available that achieve adequate levels in bone, and there are now more published studies of oral than parenteral antibiotic therapy for patients with chronic osteomyelitis. Oral and parenteral therapies achieve similar cure rates; however, oral therapy avoids...