Antiplatelet therapy remains the mainstay in preventing aberrant platelet activation in pathophysiological conditions such as myocardial infarction, ischemia, and stroke. Although there has been significant advancement in antiplatelet therapeutic approaches, aspirin still remains the gold standard treatment in the clinical setting. Limitations in safety, efficacy, and tolerability have preclude...

Since platelet activation and aggregation play a major role in thrombus formation in lumen of coronary arteries, they constitute a main target in treatment of stable ischemic heart disease and acute coronary syndromes. Antiplatelet therapy should be commenced as early as possible within the current indications in order to reduce the risk of both acute ischemic complications and recurrent athero...

Antiplatelet resistance is emerging as a significant factor in effective secondary stroke prevention. Prevalence of aspirin and clopidogrel resistance is dependent upon laboratory test and remains contentious. Large studies in cardiovascular disease populations have demonstrated worse ischemic outcomes in patients with antiplatelet resistance, particularly in patients with coronary stents. Thro...

In patients with acute ischemic stroke, what is the comparative effectiveness of anticoagu-lants (alone or with antiplatelet agents) and antiplatelet agents alone given within 14 days of stroke onset? D a t a s o u r c e s Studies were selected if they were randomized controlled trials comparing anticoagulants with antiplatelet agents, or anticoagulants plus antiplatelet agents with antiplatele...

OBJECTIVE Strokes are infrequent but potentially serious complications following carotid intervention, but antiplatelet therapy can reduce these risks. There are currently no specific guidelines on dose or duration of peri-procedural antiplatelet treatment for patients undergoing carotid intervention. Within the ongoing Asymptomatic Carotid Surgery Trial-2 (ACST-2), this study aimed at assessin...

conclusion superselective tae for lgi bleeding has a high success and low complication rate. there are no statistical correlations between the clinical success rate and several variables, including embolic material, embolization site, and anticoagulant or antiplatelet medication. patients and methods fifty-two patients who underwent superselective tae for lgi bleeding between 2003 and 2011 were...

abstract objective: patients with type 2 diabetes mellitus (dm) have a markedly increased risk of cardiovascular morbidity and mortality. there are some recommendations for prescription of aspirin in these patients. our purpose was to determine aspirin usage rate in diabetic patients and to compare it in different ages and based upon cardiovascular disease (cvd) risk factors. materials and meth...

BACKGROUND AND PURPOSE The optimal use of antiplatelet therapy for intracranial branch atheromatous disease (BAD) is not known. METHODS We conducted a prospective multicenter, single-group trial of 144 consecutive patients diagnosed with probable BAD. All patients were treated within 12 h of symptom onset to prevent clinical progression using dual antiplatelet therapy with cilostazol plus one...